| 雷莫拉宁高产菌株的选育 |
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| 引用本文： | 张永红,吴军营,张志华,王立松,郄丽萍,田红.雷莫拉宁高产菌株的选育[J].中国抗生素杂志,2010,35(4):262. |
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| 作者姓名： | 张永红 吴军营 张志华 王立松 郄丽萍 田红 |
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| 作者单位： | 华北制药集团新药研究开发有限责任公司,微生物药物国家工程研究中心河北省工业微生物代谢工程技术研究中心,石家庄050015 |
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| 摘 要： | 以雷莫拉宁产生菌RM05-55为出发菌株,首先采用紫外诱变复合链霉素抗性筛选,然后进行微波诱变,获得一株雷莫拉宁高产菌株W07-28,其发酵单位较出发菌株提高了59.3%.传代试验表明该菌株的发酵水平较稳定.
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| 关 键 词： | 雷莫拉宁 诱变 抗性选育 |
Screening of high ramoplanin producing strain |
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| Zhang Yong-hong,Wu Jun-ying,Zhang Zhi-hua,Wang Li-song,Qie Li-ping,Tian Hong.Screening of high ramoplanin producing strain[J].Chinese Journal of Antibiotics,2010,35(4):262. |
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| Authors: | Zhang Yong-hong Wu Jun-ying Zhang Zhi-hua Wang Li-song Qie Li-ping Tian Hong |
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| Abstract: | A ramoplanin producing original strain RM05-55 was treated by UV and streptomycin-resistance,and then treated by microwave radiation.A ramoplanin high-yield strain W07-28 was obtained,and its productivity was increased by 59.3% than starting strain.Submerged culture indicated that the hereditary character of this high-yield strain was stable. |
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| Keywords: | Ramoplanin Mutagenesis Resistant screening |
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