首页 | 本学科首页   官方微博 | 高级检索  
     


The current status of anti-GPCR drugs against different cancers
Authors:Sana Usman  Maria Khawer  Shazia Rafique  Zara Naz  Komal Saleem
Affiliation:1. Centre for Applied Molecular Biology, 87-West Canal Bank Road Thokar Niaz Baig, University of the Punjab, Lahore, Pakistan;2. Centre of Excellence in Molecular Biology, University of the Punjab, Lahore, Pakistan
Abstract:G protein coupled receptors (GPCRs) have emerged as the most potential target for a number of drug discovery programs ranging from control of blood pressure, diabetes, cure for genetic diseases to treatment of cancer. A panel of different ligands including hormones, peptides, ions and small molecules is responsible for activation of these receptors. Molecular genetics has identified key GPCRs, whose mutations or altered expressions are linked with tumorgenicity. In this review, we discussed recent advances regarding the involvement of GPCRs in the development of cancers and approaches to manipulating the mechanism behind GPCRs involved tumor growth and metastasis to treat different types of human cancer. This review provides an insight into the current scenario of GPCR-targeted therapy, progress to date and the challenges in the development of anticancer drugs.
Keywords:GPCRs  Anticancer therapy  Pancreatic cancer  Colon cancer  CLL  Prostate cancer  Melanoma
本文献已被 ScienceDirect 等数据库收录!
设为首页 | 免责声明 | 关于勤云 | 加入收藏

Copyright©北京勤云科技发展有限公司  京ICP备09084417号