Evaluation of antiplasmodial properties in 15 selected traditional medicinal plants from India |
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| Affiliation: | 1. Department of Pharmacognosy and Phytochemistry, Bharat School of Pharmacy, Mangalpally, Ibrahimpatnam, Hyderabad 501510, Telangana, India;2. Department of Pharm D, Bharat School of Pharmacy, Mangalpally, Ibrahimpatnam, Hyderabad 501510, Telangana, India;3. Department of Biotechnology, B. V. Patel Pharmaceutical Education and Research Development Centre, Thaltej-Gandhinagar Highway, Thaltej, Ahmedabad 380054, Gujarat, India;1. Centro de Pesquisas Rene Rachou, Laboratório de Malária, Belo Horizonte, Brazil;2. Pontifical Catholic University of Rio de Janeiro, Department of Chemistry, Rio de Janeiro, Brazil;3. University of California, San Francisco, Department of Pharmaceutical Chemistry, USA;4. Universidade Federal de Alagoas, Instituto de Química e Biotecnologia, Maceió, Brazil;1. Department of Chemistry, School of Physical, Chemical and Applied Sciences, Pondicherry University, Puducherry 605 014, India;2. UCIBIO@REQUIMTE, Departamento de Química, Faculdade de Ciências e Tecnologia, Universidade Nova de Lisboa, 2829-516 Caparica, Portugal;3. Parasitology Division, CSIR-Central Drug Research Institute, Lucknow 226031, India;4. Centre for Bioinformatics, School of Life Sciences, Pondicherry University, Puducherry 605 014, India;1. Dipartimento di Scienze Farmacologiche e Biomolecolari, Università degli Studi di Milano, Via Pascal 36, 20133 Milan, Italy;2. Dipartimento di Scienze Biomediche, Chirurgiche e Odontoiatriche, Università degli Studi di Milano, Via Pascal 36, 20133 Milan, Italy;3. Dipartimento di Scienze dei Materiali, Università degli Studi di Milano “Bicocca”, Via Cozzi 51 Milan, Italy;4. Centre de Recherche Biomoléculaire Pietro Annigoni, CERBA/LABIOGENE, Université de Ouagadougou 01 BP 364 Burkina Faso;5. Unité de Formation et de Recherche/Science de la Santé, Université de Ouagadougou, 01 BP 7021 Ouagadougou, Burkina Faso;6. Unité de Formation et de Recherche/Science de la Vie et de la Terre, Université de Ouagadougou, Burkina Faso;7. Dipartimento di Chimica, CNR-ISTM, Università degli Studi di Milano, Italy;1. Department of Medical Biotechnology, College of Biomedical Science, Kangwon National University, Chuncheon, Gangwon 24341, Republic of Korea;2. Department of Analytical Chemistry, Faculty of Pharmacy, Afyonkarahisar University of Health Sciences, Afyonkarahisar 03100, Turkey;3. Department of Physics, Faculty of Arts and Sciences, Middle East Technical University, Ankara 06800, Turkey;1. Medicinal Chemistry Division, CSIR-Central Institute of Medicinal and Aromatic Plants, Lucknow 226015, India;2. Molecular Bio-prospection Department, CSIR-Central Institute of Medicinal and Aromatic Plants, Lucknow 226015, India;3. Analytical Chemistry Division, CSIR-Central Institute of Medicinal and Aromatic Plants, Lucknow 226015, India;4. Microbial Technology and Plant Pathology Division, CSIR-Central Institute of Medicinal and Aromatic Plants, Lucknow 226015, India |
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| Abstract: | ObjectiveThe objective of this study was to evaluate the in vitro antiplasmodial properties against malaria parasite in 15 plants mentioned in Indian traditional medicine texts.MethodsIn vitro antiplasmodial activity of methanolic extracts obtained from Indian traditional medicinal plants was evaluated on Plasmodium falciparum of FCK2 and INDO strains using schizont maturation inhibition assay and parasite lactate dehydrogenase inhibition assay.ResultsMethanolic extracts of Adhatoda zeylanica, Embelia ribes, Piper nigrum and Plumbago zeylanica exhibited more than 50% inhibition in both the stains in schizont maturation inhibition assay. Methanolic extracts of seven medicinal plants exhibited antiplasmodial activity at half maximal inhibitory concentration (IC50) < 100 µg/mL, and methanolic extracts of five medicinal plants exhibited antiplasmodial activity at IC50 < 50 µg/mL in P. falciparum lactate dehydrogenase (PfLDH) inhibition assay. A. zeylanica, E. ribes and P. nigrum exhibited promising antiplasmodial activity in PfLDH inhibition assay. A. zeylanica and E. ribes exhibited improved activity against resistant in comparison to sensitive strain.ConclusionA. zeylanica and E. ribes were the most promising extracts from this study and deserve further investigation of their antiplasmodial properties. |
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| Keywords: | Medicinal plants Schizont maturation inhibition assay Lactate dehydrogenase inhibition assay Cytotoxicity |
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