| 灵芝及灵芝孢子粉的毒理学与安全性评价研究进展 |
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| 引用本文： | 俞宇寒, 宋翼升, 张立将. 灵芝及灵芝孢子粉的毒理学与安全性评价研究进展[J]. 中国现代应用药学, 2023, 40(8): 1147-1152. DOI: 10.13748/j.cnki.issn1007-7693.20222542 |
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| 作者姓名： | 俞宇寒 宋翼升 张立将 |
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| 作者单位： | 浙江工业大学长三角绿色制药协同创新中心, 杭州 310014;杭州医学院安全性评价研究中心, 杭州 310053 |
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| 摘 要： | 本文对灵芝及灵芝孢子粉的概况、灵芝孢子粉的去壁和破壁技术、灵芝孢子粉的鉴定方法进行了梳理，并重点对灵芝孢子粉毒理学各项研究(包括急性毒性、遗传毒性、重复给药毒性、幼龄动物毒性研究等)进行整理归纳，现有文献表明灵芝及灵芝孢子粉在上述毒理学试验中安全性良好，无明显毒性。
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| 关 键 词： | 灵芝 灵芝孢子粉 毒理学 安全性评价 |
| 收稿时间： | 2022-07-17 |
Research Progress on Toxicology and Safety Evaluation of Ganoderma and Ganoderma Spore Powder |
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| YU Yuhan, SONG Yisheng, ZHANG Lijiang. Research Progress on Toxicology and Safety Evaluation of Ganoderma and Ganoderma Spore Powder[J]. Chinese Journal of Modern Applied Pharmacy, 2023, 40(8): 1147-1152. DOI: 10.13748/j.cnki.issn1007-7693.20222542 |
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| Authors: | YU Yuhan SONG Yisheng ZHANG Lijiang |
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| Affiliation: | Collaborative Innovation Center of Yangtze River Delta Region Green Pharmaceuticals, Zhejiang University of Technology, Hangzhou 310014, China;Hangzhou Medical College Safety Evaluation Research Center, Hangzhou 310053, China |
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| Abstract: | In this paper, the general situation of Ganoderma and Ganoderma spore powder, the wall removal and wall breaking technology of Ganoderma spore powder, and the identification method of Ganoderma spore powder were reviewed. The toxicology of Ganoderma spore powder research(including acute toxicity test, genotoxicity test, repeated administration toxicity, juvenile animal toxicity studies, etc.) are sorted and summarized, existing literature shows that Ganoderma and Ganoderma spore powder are safe in the above toxicology tests without obvious toxicity. |
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| Keywords: | Ganoderma Ganoderma spore powder toxicology safety evaluation |
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