The emerging roles of eosinophils in mucosal homeostasis |
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| Institution: | 1. Global Health Institute, School of Life Sciences, École Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland;2. The Francis Crick Institute, 1 Midland Road, NW1 1AT, London, UK;3. University of Calgary, Cumming School of Medicine, 3330 Hospital Drive NW, T2N 4N1, Calgary, AB, Canada;4. Department of Immunology and Pathology, Central Clinical School, Monash University, The Alfred Centre, Melbourne, VIC, Australia;1. Global Health Institute, School of Life Sciences, École Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland;2. The Francis Crick Institute, 1 Midland Road, NW1 1AT, London, UK;3. University of Calgary, Cumming School of Medicine, 3330 Hospital Drive NW, T2N 4N1, Calgary, AB, Canada;4. Department of Immunology and Pathology, Central Clinical School, Monash University, The Alfred Centre, Melbourne, VIC, Australia |
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| Abstract: | Eosinophils are granulocytes, typically implicated as end-stage effector cells in type-II immune responses. They are capable of producing a wide array of pre-formed molecules which render them with vast potential to influence a wide variety of processes. Nonetheless, eosinophil research has traditionally focused on their role in anti-helminthic responses and pathophysiological processes in type-II immune disorders, such as allergy and asthma, where eosinophilia is a hallmark phenotype. However, a number of key studies over the past decade have placed this restricted view of eosinophil function into question, presenting additional evidence for eosinophils as critical regulators of various homeostatic processes including immune maintenance, organ development, and tissue regeneration. |
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