甲状腺相关性眼病泪腺病变发病机制及其诊断的研究进展

甲状腺相关性眼病(TAO)是一种与自身免疫性甲状腺疾病相关的器官特异性自身免疫疾病.此病变主要累及眼眶脂肪、眼外肌及泪腺组织.大部分TAO患者都有干眼症状,如视力下降、眼干涩、畏光、流泪和异物感等.眼表损伤导致的干眼症是TAO患者眼部不适的最常见原因.有研究证实,与TAO相关的泪腺病变可能直接参与了TAO眼表损伤的发生.本文中笔者将从TAO患者眼表改变、泪腺病变的机制及泪腺影像学等角度对TAO相关泪腺病变的研究进展进行综述,以期为进一步研究及临床治疗提供参考.

Advances on the mechanism and dignosis of lacrimal gland lesions in thyroid-associated ophthalmopathy

Thyroid associated ophthalmopathy(TAO)is an organ speeifie autoimune disease associated with autoimmune thyroid disease.TAO changed pathologically orbital fat,extraocular muscles,and lacrimal glands to some extent.The majority of patients with TAO had dry eye symptoms,such as decreased vision,photophobia,tearing.grittiness in the eye,elc.Dry eye syndrome caused by ocular surface injury was the most common cause of ocular discomfort in TAO patients.Studies have shown that lacrimal gland may be directly involved in the pathogenesis of ocular surface injury in TAO patients.The research progress of TAO related lacrimal gland lesions from the aspeets of ocular surface changes,mechanism of lacrimal gland lesions,and lacrimal gland imaging were reviewed,which could be of benifit to provide reference for further study and elinical treatment.