In Vitro Potential of Lycosin-I as an Alternative Antimicrobial Drug for Treatment of Multidrug-Resistant Acinetobacter baumannii Infections |
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| Authors: | Ling Wang Yong-Jun Wang Yin-Yin Liu Hui Li Ling-Xia Guo Zhong-Hua Liu Xiao-Liu Shi Min Hu |
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| Affiliation: | aThe Second Xiangya Hospital of Central South University, Changsha, China;bCollege of Life Sciences, Hunan Normal University, Changsha, China |
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| Abstract: | The resistance of multidrug-resistant Acinetobacter baumannii (MDRAB) isolates to most traditional antibiotics results in huge challenges for infection therapy. We investigated the in vitro activities of both l- and d-lycosin-I against MDRAB. These two compounds displayed high antibacterial activities and rapid bactericidal effects against MDRAB. Moreover, the compounds retained their activity even at high salt (Mg2+ or Ca2+) concentrations. These results demonstrate the potential of lycosin-I to be developed as a new antibiotic. |
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