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Biomarkers in acute lung injury: insights into the pathogenesis of acute lung injury |
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| Authors: | Cross L J Mark Matthay Michael A |
| Affiliation: | a Centre for Infection and Immunity, Queen’s University of Belfast, Room 01/014, Health Sciences Building, 97 Lisburn Road, Belfast, BT9 7BL, Northern Ireland, UK b Cardiovascular Research Institute, University of California, San Francisco, 505 Parnassus Avenue, M-917, San Francisco, CA 94143-0624, USA c Department of Medicine, Division of Pulmonary and Critical Care, University of California, San Francisco, 505 Parnassus Avenue, San Francisco, CA 94143-2202, USA d Department of Anesthesia, University of California, San Francisco, 505 Parnassus Avenue, San Francisco, CA 94143-2202, USA |
| Abstract: | Studies of potential biomarkers of acute lung injury (ALI) have provided information relating to the pathophysiology of the mechanisms of lung injury and repair. The utility of biomarkers remains solely among research tools to investigate lung injury and repair mechanisms. Because of lack of sensitivity and specificity, they cannot be used in decision making in patients with ALI or acute respiratory distress syndrome. The authors reviewed known biomarkers in context of their major biologic activity. The continued interest in identifying and studying biomarkers is relevant, as it provides information regarding the mechanisms involved in lung injury and repair and how this may be helpful in identifying and designing future therapeutic targets and strategies and possibly identifying a sensitive and specific biomarker. |
| Keywords: | Biomarkers Acute lung injury Acute respiratory distress syndrome Pathophysiology |
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