Association of glycosylated hemoglobin level with lipid ratio and individual lipids in type 2 diabetic patients

ObjectiveTo study the correlation of lipid ratios and individual lipid indexes of patients with type 2 diabetes with glycosylated hemoglobin (HbA_1c).MethodsSamples were collected from 128 type 2 diabetic patients (aged 19–90 years; male 72, female 56). The sera were analyzed for HbA_1c, total cholesterol (TC), triglycerides (TG), high-density lipoprotein cholesterol (HDL-C) and low-density lipoprotein cholesterol (LDL-C). According to the HbA_1c level, the patients were divided into three groups, group A (HbA_1c <7%, n=31), group B (7%?HbA_1c?10%, n=48), and group C (HbA_1c >10%, n=49). The correlation of HbA_1c with lipid ratios &; individual lipid indexes were analyzed.ResultsWith the increased level of HbA_1c, LDL-C had a significantly increasing trend (P<0.05); whereas TC went up with the increased HbA_1c, without any significant differences between three groups. There was no significant correlation between HbA_1c and TG or HDL-C. With the increased level of HbA_1c, TC/HDL-C, LDL-C/HDL-C ratios were gradually increased, with significant differences among groups (P<0.05). The lipid ratios, especially LDL-C/HDL-C ratio was more susceptible to impaired lipid metabolism in T2DM patients than individual lipid.ConclusionsLDL-C/HDL-C ratio is helpful in assessing and reducing the risk of cardiovascular disease caused by impaired lipid metabolism in type 2 diabetic patients.