| 穿琥宁中空栓的制备及质量控制方法研究 |
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| 引用本文： | 刘海净,于宝成,白秋江,吴叶红.穿琥宁中空栓的制备及质量控制方法研究[J].中国药房,2007,18(33):2586-2588. |
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| 作者姓名： | 刘海净 于宝成 白秋江 吴叶红 |
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| 作者单位： | 开滦(集团)有限责任公司医院,唐山市,063000 |
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| 摘 要： | 目的:制备穿琥宁中空栓并建立其质量控制方法。方法:以半合成脂肪酸甘油酯为基质,以聚乙二醇300或1,2-丙二醇为分散媒,制备穿琥宁中空栓;采用紫外分光光度法测定主药穿琥宁的含量,测定波长为251nm。结果:穿琥宁检测浓度在6.0～50.0μg.mL-1范围内与吸光度呈良好线性关系(r=0.9999,n=5);2种穿琥宁中空栓的质量考查符合规定。结论:本方法合理、可行。
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| 关 键 词： | 穿琥宁 中空栓 制备 紫外分光光度法 质量控制 |
| 文章编号： | 1001-0408（2007）33-2586-03 |
| 修稿时间： | 2007年2月2日 |
Preparation and Quality Control of Potassium Dehydroandrographolide Succinate Hollow Suppository |
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| LIU Haijing,YU Baocheng,BAI Qiujiang,WU Yehong.Preparation and Quality Control of Potassium Dehydroandrographolide Succinate Hollow Suppository[J].China Pharmacy,2007,18(33):2586-2588. |
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| Authors: | LIU Haijing YU Baocheng BAI Qiujiang WU Yehong |
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| Abstract: | OBJECTIVE:To prepare Potassium dehydroandrographolide succinate(PDS)hollow suppository and establish a method for its quality control.METHODS:The PDS hollow suppository was prepared with semisynthesis fatty acid glyceride as ground substances and PEG300 or 1,2 propylene glycol as disperse medium.The content of PDS was determined by ultraviolet spectrophotometry at a detection wavelength of 251nm.RESULTS:The linear concentration range of PDS was 6.0～50.0μg·mL-1(r=0.999 9,n=5).The two kinds of PDS hollow suppository were all up to the quality standard.CONCLUSION:This method is reasonable in design and feasible in technology. |
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| Keywords: | Potassium dehydroandrographolide succinate(PDS) Hollow suppository Preparation Ultraviolet spectrophotometry Quality control |
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