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| 损毁Parkinson病大鼠腹侧苍白球对纹状体内多巴胺的影响 | |
| 引用本文： | 李涛,曾水林,杨鹏,康学军,黄晓,蕭静,刘俊华.损毁Parkinson病大鼠腹侧苍白球对纹状体内多巴胺的影响[J].神经解剖学杂志,2005,21(4):405-408. |
| 作者姓名： | 李涛 曾水林 杨鹏 康学军 黄晓 蕭静 刘俊华 |
| 作者单位： | 1. 东南大学,神经生物学研究所,南京,210009 2. 东南大学,公共卫生学院,南京,210009;东南大学,生物电子学国家重点实验室,南京,210009 3. 东南大学,公共卫生学院,南京,210009 |
| 基金项目： | 江苏省自然科学基金(BK2001007)资助项目 |
| 摘 要： | 应用6羟基多巴胺(6OHDA)制备Parkinson病(PD)大鼠模型,插入电极通过直流电毁损腹侧苍白球(VP),观察毁损术后PD大鼠旋转行为的变化,并应用高压液相色谱检测纹状体内多巴胺(DA)及3,4二羟甲基苯丙氨酸(DOPAC)和去甲肾上腺素(NA)的含量。结果显示:直流电毁损VP可使PD模型大鼠的旋转行为明显减少;毁损侧纹状体内DA的含量减少,DOPAC和NA的含量增加。上述结果提示VP毁损可明显改善PD大鼠的旋转行为,此效应可能与抑制VP的异常兴奋有关。 |
| 关 键 词： | Parkinson病 多巴胺 腹侧苍白球 纹状体 大鼠 |
| 修稿时间： | 2004年11月29 |
CHANGES OF THE CONTENT OF DOPAMINE IN STRIATUM INDUCED BY LESION OF VENTRAL PALLIDUM OF PARKINSON'S DISEASE RATS |
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| Li Tao,Zeng Shuilin,Yang Peng,Kang Xuejun,Huang Xiao,Xiao Jing,Liu Junhua.CHANGES OF THE CONTENT OF DOPAMINE IN STRIATUM INDUCED BY LESION OF VENTRAL PALLIDUM OF PARKINSON''''S DISEASE RATS[J].Chinese Journal of Neuroanatomy,2005,21(4):405-408. | |
| Authors: | Li Tao Zeng Shuilin Yang Peng Kang Xuejun Huang Xiao Xiao Jing Liu Junhua |
| Institution: | Li Tao~1,Zeng Shuilin~1,Yang Peng~1,Kang Xuejun~2,3,Huang Xiao~2,Xiao Jing~2,Liu Junhua~1 |
| Abstract: | The model of Parkinson's Disease(PD) was made by injecting 6-hydroxydopamine (6-OHDA) into the left substantia nigra pars compacta (SNc) and ventral tegmental area (VTA) of rats. After damaging ventral pallidum (VP) of these rats, we observed the changes of rotation behaviour, and detected the content of dopamine (DA), 3,4-dihydroxyphenyleddikesyre (DOPAC) and norepinephrine (NA) in striatum by high pressure liquid chromatography (HPLC) with fluorescence detection analysis.The results showed that after the lesion, the rotating behaviour decreased markedly, and the content of DA was strikingly decreased, while the content of DOPAC and NA was increased in striatum. The results indicate that lesion of VP induced decreased rotation bchaviour, the rotation behaviour of these rats decreased markedly, this might be resulted from the abnormal discharge inhibiting of the VP. |
| Keywords: | Parkinson's disease dopamine ventral pallidum striatum rat |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ | |