心力衰竭患者脑钠肽与心功能临床相关性研究

目的：探讨心力衰竭患者血浆脑钠肽（BNP）水平与心力衰竭严重程度、左室功能等因素的相关性.方法： 将161例入选者分为正常对照组（42例）与HF组（119例）,采用放射免疫法测定各组患者血浆BNP水平;使用心脏彩色多普勒超声诊断仪测定并比较各组左室射血分数（LVEF）、左心室舒张末期横径（LVEDd）.结果： 心力衰竭患者BNP水平显著高于对照组（P＜0.01）,且BNP水平随着心功能NYHA分级的增加而显著增高,心力衰竭各组间BNP水平、LVEF、LVEDd差异均有统计学意义（P＜0.05～0.01）.BNP水平与LVEF呈负相关（r=-0.685, P＜0.001）,而与LVEDd呈正相关（r=0.624, P＜0.001）.结论： 心力衰竭患者血浆BNP水平随着心力衰竭严重程度的增加而升高,并能较好的反映左室功能状态.

A study of the correlation between the serum brain natriuretic peptide levels and the cardiac function in patients with heart failure

Objective: To investigation the correlation between the serum brain natriuretic peptide (BNP) levels and the severity of heart failure (HF) as well as left ventricular function (LVF) in patients with heart failure. Methods: One hundred and nineteen patients with HF and 42 control subjects were investigated by measuring the serum BNP levels, the left ventricular ejection fraction (LVEF) and left ventricular end-diastolic diameter (LVEDd). Results: The serum BNP levels in patients with HF were markedly higher than those of control subjects (P<0.01), and the increase of BNP levels was closely correlated with the severity of NYHA functional class, The BNP levels were correlated negatively with the LVEF (r=-0.685, P<0.001) and positively with the LVEDd (r=0.624, P<0.001). Conclusion: The increase of BNP levels is closely correlated with the severity of HF, further more, the BNP levels may reflect the LVF clearly.