Chlorpromazine and brain-stimulation reward: Potentiation of effects by naloxone |
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| Authors: | Ralph U. Esposito William Perry Conan Kornetsky |
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| Affiliation: | Laboratory of Behavioral Pharmacology, Boston University School of Medicine, Boston, MA 02118, USA |
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| Abstract: | Chlorpromazine (0.25–2.0 mg/kg IP) raised the threshold for brain stimulation reward in a dose-dependent manner in rats. Naloxone (4.0 mg/kg IP) administered alone was without effect on this behavior. However, this dose of naloxone administered concurrently with chlorpromazine produced substantial potentiation of the threshold increases. These resultsstrongly suggest a catecholaminergic-enkephalinergic involvement in the regulation of central reward processes. |
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| Keywords: | Brain-stimulation reward Chlorpromazine Naloxone Enkephalin Schizophrenia |
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