Naloxone blocks the effect of diazepam and meprobamate on conflict behaviour in rats |
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| Authors: | Th. Duka R. Cumin W. Haefely A. Herz |
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| Affiliation: | 1. Department of Neuropharmacology, Max-Planck-Institut für Psychiatrie Kraepelinstrasse 2, D-8000 München 40, FRG;2. Pharmaceutical Research Department, F. Hoffmann-La Roche Ltd. CH-4002 Basel, Switzerland |
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| Abstract: | The effect of naloxone on the anticonflict action of diazepam was studied in a model involving foot shock-induced suppression of food-rewarded operant behaviour. Both 1 and 10 mg/kg naloxone SC abolished the increase in punished responding produced by diazepam and chlordiazepoxide. Naloxone also blocked the anticonflict effect of meprobamate. These observations are discussed in terms of a possible involvement of endogenous opioid peptides in the anxiolytic effects of tranquillizers. |
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| Keywords: | Antianxiety Diazepam Meprobamate Naloxone Opioid peptides |
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