Pimozide attenuates conditioned taste preferences induced by self-stimulation in rats |
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Authors: | Aaron Ettenberg Norman White |
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Affiliation: | 1. Arthur Vining Davis Center for Behavioral Neurobiology, The Salk Institute, San Diego, CA 92138, USA;2. Department of Psychology, McGill University, Montreal, Quebec, Canada |
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Abstract: | Conditioned taste preferences (CTPs) were observed in rats who drank flavored water followed by a session of self-stimulation. Control groups that did not self-stimulate did not exhibit CTPs. Other taste/SS pairings conducted under the influence of the dopamine receptor antagonist pimozide (0.1 or 0.3 mg/kg, IP) resulted in dose-dependent reductions in the size of the CTPs. No evidence of any aversive effects (conditioned tast aversions) of the pimozide treatment were observed in the no-stimulation control groups. These data suggest that, in addition to its effects on responding, low doses of pimozide reduce the rewarding properties of self-stimulation. |
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Keywords: | Pimozide Brain-stimulation reward Conditioned taste preferences Dopamine Self-stimulation |
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