Subchronic Toxicity Evaluation of Tridecyl Acetate in Rats

Subchronic Toxicity Evaluation of Tridecyl Acetate in Rats.DAUGHTREY, W. C, SMITH, J. H., HINZ, J. P., AND BILES, R. W.(1990). Fundam. Appl. Toxicol. 14, 104–112. Tridecyl acetatewas administered to male and female Sprague-Dawley rats by oralgavage, 5 days per week for 13 weeks (90 days). Treated ratsreceived daily doses of 0.1, 0.5, or 1.0 g/kg/day and controlrats received distilled water at a dose of 1.0 g/kg/day. After45 days an interim termination was made to evaluate potentialhematologic or hepatic effects of tridecyl acetate. Blood sampleswere collected for routine hematology and serum chemistry determinationsand liver tissue was obtained for histological examination.After 90 days all animals were necropsied. Blood samples wereobtained and selected organs were weighed and prepared for histologicalexamination. Treatment-related effects observed in the mid andhigh dose groups consisted of (1) increased liver weights and/orliver/body weight ratios in both sexes at the interim and 13week termination, (2) increased kidney weights and/or kidney/bodyweight ratios in both sexes at the terminal necropsy, (3) histopathologicevidence of hydrocarbon nephropathy in males, and (4) a slightdecrease in serum glucose levels in male rats at both the interimand terminal necropsies. The increases in liver weight are believedto be a normal physiological response to a chemkal challenge.The nephropathy produced by tridecyl acetate is characteristicof that produced by a diverse group of hydrocarbons and, todate, appears to be limited to male rats. The low dose in thisstudy was a no observed effect level. These results are indicativeof an overall low degree of systemic toxicity following subchronicoral administration of tridecyl acetate at doses up to 1 g/kgbody weight.