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NADPH diaphorase activity in the posterior pituitary: relation to neuronal function |
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| Authors: | Stephen M. Sagar and Donna M. Ferriero |
| Affiliation: | aNeurology Service, San Francisco Veterans Administration Medical Center University of California, San Francisco, CA 94143 U.S.A. bDepartment of Neurology, University of California, San Francisco, CA 94143 U.S.A. |
| Abstract: | Magnocellular neurons of the paraventricular and supraoptic nuclei, fibers of the medial basal hypothalamus, and the posterior pituitary gland all stain histochemically for NADPH diaphorase activity (NADPHd). Following 8 days of salt loading to stimulate the hypothalamo-neurohypophyseal system, NADPHd activity, as determined by a spectrophotometric assay, is markedly increased in the posterior pituitary gland but not in the hypothalamus of rats. Therefore, NADPHd activity in this system correlates with neuronal function and may provide a convenient method for the assessment of neuronal activity in selected neuronal populations. |
| Keywords: | NADPH diaphorase Neurohypophysis Vasopressin Oxytocin Functional activity |
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