| IL－6和TNF对白血病细胞的调控作用及意义 |
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| 引用本文： | 罗云萍,黄宗干.IL－6和TNF对白血病细胞的调控作用及意义[J].现代免疫学,1996(3). |
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| 作者姓名： | 罗云萍 黄宗干 |
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| 作者单位： | 重庆医科大学临床血液教研室 |
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| 摘 要： | 通过诱导急性白血病肿瘤细胞自分泌白细胞介素６和肿瘤坏死因子，利用急性白血病原代肿瘤细胞和肿瘤细胞系ＨＬ－６０和Ｋ５６２，分别观察了ＩＬ－６和ＴＮＦα对急性白血病细胞的调控作用。结果发现，急性白血病细胞存在着ＩＬ－６和ＴＮＦα的自分泌作用，而ＴＮＦα和ＩＬ－６对白血病细胞则有诱导分化作用；进一步研究发现，ＴＮＦα对急性白血病细胞株还可呈现生长抑制作用；而ＩＬ－６则可表现为生长促进作用。ＩＬ－６和ＴＮＦα对急性白血病细胞的这种凋控在白血病的发病和免疫调控治疗中将有意义。
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| 关 键 词： | 白血病细胞，肿瘤坏死因子，白细胞介素6 |
Effect of Recombinant Tumor Necrosis Factor and Interleukin 6 on Proliferation and Differentiation of Leukemia cells |
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| Luo Yunping, Huang Zonggan.Effect of Recombinant Tumor Necrosis Factor and Interleukin 6 on Proliferation and Differentiation of Leukemia cells[J].Current Immunology,1996(3). |
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| Authors: | Luo Yunping Huang Zonggan |
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| Abstract: | To evaluate the role of interleukin 6 and tumor necrosis factor in pathogenesis of acute leukemia,the autocrine and induction of interleukin 6 and tumor necrosis factor in acute leukemia cells and the effect of recombinant tumor necrosis factor and interleukin 6 on proliferation and differentiation of leukemia cells were observed in this studies. The results indicated that both tumor necrosis factor and interleukin 6 participated in leukemia blasts and regulation of growth in autocrine form and inducing differentiation. Futherly, tumor necrosis factor appeared the effect of inhibition of growth on acute leukemia cells,but interleukin 6 showed promotion of growth to leukemia cells. It is suggested that this effect of tumor necrosis factor and interleukin 6 on leukemia cells play an important role in pathogenesis of acute leukemia. |
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| Keywords: | acute leukemia cell TNF IL-6 |
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