| 锂离子对淋巴细胞丝裂原反应的影响 |
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| 引用本文： | 李品兰,薛国荣,蒋正明,张明富.锂离子对淋巴细胞丝裂原反应的影响[J].华中科技大学学报(医学版),1990(1). |
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| 作者姓名： | 李品兰 薛国荣 蒋正明 张明富 |
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| 作者单位： | 同济医科大学实验医学研究中心免疫室
(李品兰，薛国荣，蒋正明)，同济医院检验科(张明富) |
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| 摘 要： | 本文通过使用肌醇-1-磷酸酶抑制剂-锂离子(Li~+)及~3H-TdR掺合法研究了4,5-二磷酸-磷脂酰肌醇(PIP_2)代谢对正常人以及不同病人淋巴细胞丝裂原诱导的增殖反应的影响。在未经Li~+处理的外周血淋巴细胞经丝裂原刺激后迅速增殖分化,以对植物血凝素(PHA)的反应最强,经用Li~+处理后淋巴细胞的增殖反应明显减弱或抑制。结果提示:肌醇-1-磷酸酶的活性受抑可减弱或抑制丝裂原诱导的淋巴细胞增殖反应。
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| 关 键 词： | 肌醇-1-磷酸酶 锂 第二信使 磷脂酰肌醇 淋巴细胞 |
The Effect of Li~+ on Growth Signal Transduction of Mitogen-induced Proliferation in Lymphocytes |
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| Li Pinlan,Xue Guprong,Jiang Zhengming,Zhang Mingfu.The Effect of Li~+ on Growth Signal Transduction of Mitogen-induced Proliferation in Lymphocytes[J].Journal of Huazhong University of Science and Technology(Health Sciences),1990(1). |
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| Authors: | Li Pinlan Xue Guprong Jiang Zhengming Zhang Mingfu |
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| Institution: | Li Pinlan,Xue Guprong,Jiang Zhengming,Zhang Mingfu. Department of Immunology,Research Center of Experimental Medicine,Tongji Medical University,Wuhan |
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| Abstract: | The effects of Li+,an inhibitor of myo-inositol-1-phosphatase,on phosphatibylinositol metabolism were studied by mitogen-induced lymphocytes proliferation.When the lymphocytes were incubated in the presence of mitogen:PHA,ConA or PWM,the rates of 3H-TdR incorporation significantly increased.But this effect was inhibited by Li+.The result revealed that Li+ diminished and inhibited mitogen-induced proliferation of lymphocytes by decreasing the activity of myo-ino-sitol-1-phosphatase in metabolism of PIP2 which is important for the growth signal transduction. |
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| Keywords: | myo-inositol-1-phosphatase lithium second messenger phosphatldy-linositol 4 5-biphosphate (PIP_2) lymphocytes |
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