哮喘患儿血清白细胞介素-16、-10和免疫球蛋白E测定的意义

目的探讨哮喘患儿血清IL-16、IL-10和IgE水平测定的意义。方法对18例哮喘患儿及对照组14例健康儿童进行IL-16、IL-10和IgE水平测定并作相关性分析。结果哮喘患儿IL-16、血总IgE水平明显高于对照组P<0.05,P<0.01,而IL-10水平则低于对照组(P<0.05)。哮喘患儿血清IL-16水平与总IgE呈正相关(r=0.715P<0.01);IL-10水平与IgE呈负相关(r=-0.885P<0.01)。结论哮喘患儿气道炎症与IL-16的升高、IL-10降低有关,提示可针对IL-16、IL-10在气道炎症中作用的不同特点采取治疗十分必要。

Measurement of Serum Interleukin-16,-10 and Immunoglobulin E in Asthmatic Children and Its Significance

Objective To discuss the level and its relativity analysis of IL-16 and IgE in asthmatic children .Methods Compare and analyze the level of IL-16,IL-10 and IgE between 18 asthmatic children and 14 healthy children.Results The serum level of IL-16 and IgE in asthmatic children was much higher than the contrast, P< 0.05, P <0.01, but IL-10 was lower than the contrast.Relativive analysis, the serum level of IL-16 was positive relative to all IgE for asthmatic children( r =0.715 P <0.01).Meanwhile, IL-10 was negative ( r =-0.885 P <0.01).Conclusions The serum level of IL-16 is positively relative to all IgE for asthmatic children. Meanwhile IL-10 is negative. This conclusion proves that asthma respiratory inflammation is related to the increase of IL-16 and the decrease of IL-10, which shows us the necessity of the therapy according to the different properties of IL-16,IL-10 in respiratory inflammation.