| Smac与恶性血液病 |
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| 引用本文： | 陈湘磊,王少元. Smac与恶性血液病[J]. 医学综述, 2009, 15(8): 1165-1167 |
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| 作者姓名： | 陈湘磊 王少元 |
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| 作者单位： | 1. 福建医科大学附属协和医院血液病研究所,福州,350001
2. 福建医科大学附属协和医院血液科,福州,350001 |
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| 基金项目： | 国家自然科学基金，福建省自然科学基金 |
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| 摘 要： | Smac是一种存在于线粒体中,并具有调节细胞凋亡功能的蛋白质。Smac可释放入胞质,参与广泛的生物学效应。研究发现,Smac与恶性血液肿瘤的发生、发展、预后及化疗的耐受有关。了解Smac的生物学功能及其与恶性血液肿瘤的关系,选择性地调控其生物学活性,可能为恶性血液肿瘤的治疗提供一个新的途径。
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| 关 键 词： | Smac 恶性血液肿瘤 化疗 |
Smac and Malignant Hematologic Diseases |
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| CHEN Xiang-lei,WANG Shao-yuan. Smac and Malignant Hematologic Diseases[J]. Medical Recapitulate, 2009, 15(8): 1165-1167 |
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| Authors: | CHEN Xiang-lei WANG Shao-yuan |
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| Affiliation: | CHEN Xiang-lei , WANG Shao-yuan. ( 1. Research Institute of Hematology,the Affiliated Union Hospital,Fujian Medical University,Fuzhou 350001, China; 2. Department of Hematology,the Affiliated Union Hospital ,Fujian Medical University,Fuzhou 350001, China) |
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| Abstract: | Smac is present in the mitochondria and an adjustment of apoptosis protein. Smac can release from mitochondria to cytoplasms. Smac can be observed in many biological effects. Many study indicated that Smac correlates with prognosis and drug resistance of malignant hematologic disorder besides neoplasm genesis and growth. We can selectively regulate Smae biologic activity after explore Smac biological functions and relations with malignant neoplastic hematologic disorders,which may become a new therapeutic approach of malignant hematologic disease. |
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| Keywords: | Smac |
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