| P57KIP2蛋白在肝细胞癌中的表达及意义 |
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| 引用本文： | 朱星屹,王广田,庞志刚,刘超,赵玉洲,薛飞,孙建军. P57KIP2蛋白在肝细胞癌中的表达及意义[J]. 医药论坛杂志, 2005, 26(6): 13-14 |
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| 作者姓名： | 朱星屹 王广田 庞志刚 刘超 赵玉洲 薛飞 孙建军 |
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| 作者单位： | 郑州大学第二附属医院,郑州市,450014;郑州大学第二附属医院,郑州市,450014;郑州大学第二附属医院,郑州市,450014;郑州大学第二附属医院,郑州市,450014;郑州大学第二附属医院,郑州市,450014;郑州大学第二附属医院,郑州市,450014;郑州大学第二附属医院,郑州市,450014 |
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| 摘 要： | 目的研究p57KIP2蛋白在肝细胞癌中的表达情况,并探讨其意义。方法应用免疫组织化学S-P法检测63例肝细胞癌石蜡包埋标本和38例癌旁组织中p57KIP2蛋白的表达情况。结果肝细胞癌p57KIP2的阳性表达率为46.0%,显著低于癌旁组织78.9%(P<0.01),并与肝细胞癌的病理分级、肿瘤大小、有无包膜及门静脉癌栓相关。结论p57KIP2蛋白表达的下调可能与肝细胞癌发生发展有关。
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| 关 键 词： | 肝细胞癌 p57KIP2 免疫组织化学 |
| 文章编号： | 1672-3422(2005)06-0013-02 |
| 修稿时间： | 2004-12-20 |
Expression of p57KIP2 Protein in Hepatocellular Carcinoma and Its Significance |
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| ZHU Xingyi,WANG Guangtian,PANG Zhigang,et alThe Second Affiliated Hospital of Zhengzhou University,Zhengzhou ,China. Expression of p57KIP2 Protein in Hepatocellular Carcinoma and Its Significance[J]. Journal of Medical Forum, 2005, 26(6): 13-14 |
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| Authors: | ZHU Xingyi WANG Guangtian PANG Zhigang et alThe Second Affiliated Hospital of Zhengzhou University Zhengzhou China |
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| Affiliation: | ZHU Xingyi,WANG Guangtian,PANG Zhigang,et alThe Second Affiliated Hospital of Zhengzhou University,Zhengzhou 450003,China |
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| Abstract: | Objective To investigate the expression of p57~(KIP2) protein in hepatocellular carcinoma cells and its significance. Methods p57~(KIP2) protein expression was detected by S-P immunohistochemistry in 63 tumor tissues of hepatocellular carcinoma and 38 adjacent hepatic tissues.Results p57~(KIP2) protein positive-expression rate in tumor tissue of hepatocellular carcinoma was 46.0%,which was significantly lower than 78.9% in adjacent hepatic tissues(P<0.01).It has lower expression in hepatocellular carcinoma with advance stage,larger size,poor capsula,portal embolus.Conclusion The down regulation of p57~(KIP2) protein may be related to the genesis and progress of hepacellular carcinoma. |
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| Keywords: | Hepatocellular carcinoma p57~(KIP2) Immunohistochemistry |
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