胺碘酮治疗老年器质性心脏病所致室性心律失常的疗效

【目的】评价胺碘酮对老年器质性心脏病室性心律失常患者的疗效。【方法】入选经心电图及Holter确诊的56例室性心律失常患者，接受静脉加口服或单纯口服胺碘酮治疗，观察治疗前后心律失常改善情况及药物安全性。【结果】10例恶性室性心律失常电复律后使用静脉胺碘酮治疗7例有效，口服胺碘酮治疗6个月有效率达92．7％，29例患者治疗后发生轻度QTC延长，22例发生窦缓，1例发生甲状腺功能减低，6例静脉治疗者出现心功能恶化，所有患者用药后均未发现肝功能、外周血象、皮肤或周围神经异常。【结论】胺碘酮治疗老年器质性心脏病所致室性心律失常安全、有效。

Clinical Efficacy of Amiodarone for the Treatment of Ventricular Arrhythmia in Elderly Patients with Organic Heart Disease

Objective]To evaluate the effect of amiodarone for the treatment of ventricular arrhythmia in elderly patients with organic heart disease. Methods]Fifty six patients who were diagnosed by EKG or Hoher as ventricular arrhythmia were enrolled in this study. All patients accepted amiodarone treatment. The therapeutic effect and safety of amiodarone were observed. Results]Intravenous injection of amiodarone was effective for treating high-risk ventricular arrhythmia. The effective rate of taking amiodarone orally for 6 months was 92.7 %, in which 29 patients occurred QT intervals prolonged slightly, 22 sinus bradycardia, 1 thyroid hypofunction and 6 deterioration of heart function. No abnormality of liver function, hemogram, skin and pe ripheral nerve after treatment was found. Conclusion] Amiodarone can treat ventricular arrhythmia in elderly patients with organic heart disease safely and effectively.