非酒精性脂肪性肝病与结直肠癌

非酒精性脂肪性肝病（NAFLD）是肥胖和代谢综合征（MS）累及肝脏的表现,近来愈来愈多的研究显示NAFLD与结直肠癌（CRC）发生密切相关,伴随的胰岛素抵抗和系统性低度炎症反应可能参与了结直肠腺瘤和CRC的发病,但是NAFLD对于CRC风险增加的具体机制尚未完全明确。本文主要综述了NAFLD与结直肠腺瘤和CRC发生的相互关系及其可能的机制。

What role the nonalcoholic fatty liver disease play in carcinogenesis of colorectal cancer

Nonalcoholic fatty liver disease （NAFLD） is the hepatic manifestation of obecity and metabolic syndrome （MS）. Recently, more and more studies have shown the NAFLD is closely related to the occurrence of colorectal cancer （CRC）. The insulin resistance and systemic low-grade inflammation in the process of NAFLD may be involved in the carcinogenesis of colorectal adenoma and CRC. However, the mechanism by which the NAFLD increase the risk of CRC is not fully understood. In this article, we reviews the possible mechanisms NAFLD increase the colorectal adenomas and CRC occurrence.