MMP-2、VEGF和PTEN在乳腺癌中的表达及其临床意义

目的探讨基质金属蛋白酶(MMP-2)、血管内皮生长因子(VEGF)和抑癌基因PTEN在乳腺癌组织中的表达及其与乳腺癌浸润和转移的关系。方法应用免疫组织化学方法,对50例乳腺癌(有腋淋巴结转移者22例,无腋淋巴结转移者28例)的MMP-2、VEGF和PTEN的表达情况进行检测分析,并用多因素COX比例风险模型分析患者的预后。结果MMP-2、VEGF、PTEN在腋淋巴结转移组和无转移组的表达均具有显著性差异(P<0.01)。MMP-2和VEGF与乳腺癌腋淋巴结转移呈正相关,而PTEN与乳腺癌腋淋巴结转移呈负相关。结论在乳腺癌组织中,MMP-2与VEGF的过表达和PTEN的缺失可能提示腋淋巴结转移,可以作为乳腺癌的预后指标。

Expression of MMP-2, VEGF, PTEN and their significance in breast cancer

Objective:To study the expression of matrix metalloproteinase-2(MMP-2),vascular endothelial cell growth factor(VEGF),PTEN in breast cancer and investigate their associations wih invasion and metastasis. Methods:The expressions of MMP-2,VEGF and PTEN were examined in 50 cases of breast carcinoma including 22 cases with axillary lymph node metastasis and 28 cases without axillary lymph node metastasis by immunohistochemistry. The relationship between these expressions and prognosis was analyzed by Multivariable Cox proportional hazards model. Results:The expressions of MMP-2,VGGF and PTEN in lymph node metastasis group and in no lymph node metastasis group were significantly different(P<0.01). MMP-2 and VEGF were positive correlated with axillary lymph node metastasis in breast cancer, while PTEN was negative correlated with axillary lymph node metastasis. Conclusion:In breast carcinoma, the excessive expression of MMP-2 and VEGF and the Absence of PTEN may indicate axillary lymph node metastasis. The expressions of these proteins are the predictors for prognosis of breast carcinoma.