Protective Effects of Ambroxol in Hypothermic Liver Preservation: A Transplant Study |
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| Authors: | Gerald Drews Andrea Tannapfel Hans-Georg Gnauk Daniel Palmes Rosemarie Martin Johann Hauss Hans-Ullrich Spiegal |
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| Institution: | Department of Surgery, Division of Frontier Medical Science, Programs for Biomedical Research, Graduate School of Biomedical Science, Hiroshima University, Hiroshima, Japan |
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| Abstract: | The bronchosecretolytic agent ambroxol added to histidine-tryptophan-ketoglutarate (HTK) solution has recently been shown to protect cold stored rat hepatocytes. The aim of the present study was to confirm these observations in a rat liver transplantation model. Before orthotopic liver transplantation, donor livers from 30 syngeneic Wistar rats were assigned to three groups (n = 10): (A) in situ flush (ISF) and ½-h cold storage (CS) with HTK solution, (B) ISF and 3-h CS with HTK, and (C) ISF and 3-h CS with HTK + 10-3 |
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| Keywords: | Ambroxol Liver Preservation Liver Transplantation |
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