Propolis reduces bacterial translocation and intestinal villus atrophy in experimental obstructive jaundice |
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Authors: | Sabuncuoglu Mehmet Zafer Kismet Kemal Kilicoglu Sibel Serin Kilicoglu Bulent Erel Serap Muratoglu Sabahattin Sunay Asli Elif Erdemli Esra Akkus Mehmet Ali |
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Affiliation: | 1. 4th General Surgery Department,Ankara Training and Research Hospital, Ulucanlar, Ankara 06340,Turkey 2. Department of Histology and Embriology,Ufuk University School of Medicine, Ankara 06520, Turkey 3. Microbiology Department, Ankara Training and Research Hospital, Ulucanlar, Ankara 06340, Turkey 4. Food Engineer, Balparmak Pazarlama, Cekmekoy 34760, Istanbul, Turkey 5. Department of Histology and Embriology, Ankara University School of Medicine, 06100, Ankara, Turkey |
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Abstract: | AIM: To investigate the effects of propolis on bacterial translocation and ultrastructure of intestinal morphology in experimental obstructive jaundice. METHODS: Thirty Wistar-Albino male rats were randomly divided into three groups, each including 10 animals: group I, sham-operated; group II, ligation and division of the common bile duct (BDL); group III, BDL followed by oral supplementation of propolis 100 mg/kg per day. Liver, blood, spleen, mesenteric lymph nodes, and ileal samples were taken for microbiological, light and transmission electron microscopic examination on postoperative 7th d after sacrification. RESULTS: The mean number of villi per centimeter and mean mucosal height of the propolis group were significantly different in the BDL group (P = 0.001 and 0.012, respectively). The electron microscopic changes were also different between these groups. Sham and BDL + propolis groups had similar incidence of bacterial translocation (BT). The BDL group had significantly higher rates of BT as compared with sham and BDL + propolis groups. BT was predominantly detected in MLNs and the most commonly isolated bacteria was Escherichia coli. CONCLUSION: Propolis showed a significant protective effect on ileal mucosa and reduced bacterial translocation in the experimental obstructive jaundice model. Further studies should be carried out to explain the mechanisms of these effects. |
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Keywords: | Obstructive jaundice Bacterial translocation Ileal morphology |
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