Synthesis and antifungal activity of novel pyrano[2',3':4,5]thiazolo[2,3-b]quinazolines, pyrido[2',3':4,5]thiazolo[2,3-b]quinazolines and pyrazolo[2',3':4,5]thiazolo[2,3-b]quinazolines |
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Authors: | Abdel-Gawad S M El-Gaby M S Ghorab M M |
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Institution: | Department of Chemistry, Faculty of Science (Girl's), Al-Azhar University, Cairo, Egypt. |
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Abstract: | The starting materials thiazolo2,3-b]quinazolines (5a,b) were obtained in one pot synthesis by treating octahydroquinazoline (2) with chloroacetic acid and aromatic aldehydes. Thiazoloquinazoline (5) was reacted with CH2(CN)2/piperidine and CH2(CN)2/NaOH (CH3OH), to furnish pyrano2',3':4,5]thiazolo2,3-b]quinazolines (6a,b) and pyrido2',3':4,5]thiazolo2,3-b]quinazoline (7), respectively. Refluxing of 5a with NH2CSNH2/KOH and hydrazines in ethanol furnished the corresponding, 1,3]thiazino4'5':4,5]thiazolo2,3-b]quinazoline (10) and pyrazolo3',4':4,5]thiazolo2,3-b]quinazolines (11a,b), respectively. Antifungal activity was shown for some of the synthesized compounds. |
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