| 血清维生素D代谢产物水平与肾脏疾病的关系 |
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| 引用本文： | 薛延,杨守礼.血清维生素D代谢产物水平与肾脏疾病的关系[J].中华内分泌代谢杂志,1991,7(2):84-86. |
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| 作者姓名： | 薛延 杨守礼 |
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| 作者单位： | 北京积水潭医院生化研究室
(薛延，李文菁)，北京积水潭医院内科
(祝恕德，魏琴娥，王丹琪)，中日友好医院同位素研究室
(杨守礼，胡明)，北京友谊医院儿科
(李贵)，北京友谊医院儿科(阎田玉) |
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| 摘 要： | 用竞争性蛋白结合法和放射受体法观察了46例肾脏病患者血清维生素D代谢产物的变化。结果表明,各类肾脏病患者血清25-羟维生素D_3的含量均低于正常对照组,平均下降了41.2％(P<0.01),以尿毒症患者最低,表明肾脏病患者维生素D的营养状态是低下的。尿毒症和肾病综合征患者,血清1,25-二羟维生素D_31,25(OH)_2D_3]亦明显下降,分别比对照组降低了33.5％和42.4％(P<0.05),而慢性肾功能不全患者血清1,25(OH)_2D_3与肾功能不全的程度呈负相关。作者还对肾脏疾病维生素D代谢产物水平降低的机理进行了讨论。
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| 关 键 词： | 维生素D代谢产物 慢性肾功能不全 肾病综合征 |
THE RELATIONSHIP BETWEEN SERUM LEVELS OF VITAMIN D METABOLITES AND RENAL DISEASE |
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| Xue Tan,et al..THE RELATIONSHIP BETWEEN SERUM LEVELS OF VITAMIN D METABOLITES AND RENAL DISEASE[J].Chinese Journal of Endocrinology and Metabolism,1991,7(2):84-86. |
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| Authors: | Xue Tan |
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| Institution: | Xue Tan,et al.
Laboratory of Biochemistry,Beijing Ji Shut Tan Hospital,Beijing |
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| Abstract: | Alterations of serum vitamin D metabolites were observed by competitive protein-binding assay and radioreceptor assay in 46 patients with renal disease inckding chronic renal failure (CRF), nephrotic syndrcme (NS) and nephritis. The results indicated that serum 25-hydroxy-vitamin D (25-OHD) level decreased 41.2% as compared with the control group (P<0.01) and the lowest was found in uremic patients. It showed that vitamin D level is low in renal disease. Meanwhile serum 1,25-dihydroxy-vitamin D 1,25(OH)2D3] levels in uremia and NS patients decreased 33.5^ and 42.2% respectively (P<0.05) as compared with control group; serum l,.25(OH)2D3levels in CRF patients were negatively correlated with the severity of renal failure. The mechanism of low vitamin D metabolites in renal disease was discussed. |
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| Keywords: | Vitamin D metabolites Renal failure chronic Nephrotic syndrome |
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