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| 恶性卵巢上皮肿瘤的P53基因点突变及其意义 | |
| 引用本文： | 王振国,朱红,赫朝霞. 恶性卵巢上皮肿瘤的P53基因点突变及其意义[J]. 中国医师杂志, 2003, 5(4): 482-483 |
| 作者姓名： | 王振国 朱红 赫朝霞 |
| 作者单位： | 1. 解放军第309医院妇产科,北京,100091 2. 空军北京医院妇产科 3. 全国妇女联合会 |
| 摘 要： | 目的 为揭示P53抗癌基因与卵巢上皮肿瘤发病学的关系，对P53基因5—8外显子突变进行了检测。方法 采用聚合酶链反应—DNA单链构象多态性分析法，以同期良性卵巢上皮肿瘤作对照组。结果 30例卵巢良性上皮肿瘤中P53基因突变3例(10％)；而50例恶性卵巢上皮肿瘤中发生突变19例(38％)，经x^2检验，差异有显著性(P＜0．05)。但不同组织学分级时P53基因点突变差异不显著(P＞0．05)。结论 恶性卵巢上皮肿瘤P53基因5—8外显子点突变发生率，明显高于卵巢良性上皮肿瘤，该种突变可能与恶性卵巢上皮肿瘤的发生有关。但P53基因5—8外显子点突变与组织学分级天关。 |
| 关 键 词： | 卵巢上皮肿瘤 恶性 P53基因 点突变 |
| 文章编号： | 1008-1372(2003)04-0482-02 |
| 修稿时间： | 2002-03-15 |
Mutation of P53 Gene in Ovarian Malignant Epithelial Tumors and Its Clinical Significance |
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| WANG Zhen-guo,ZHU Hong,HE Zhao-xia. Mutation of P53 Gene in Ovarian Malignant Epithelial Tumors and Its Clinical Significance[J]. Journal of Chinese Physician, 2003, 5(4): 482-483 | |
| Authors: | WANG Zhen-guo ZHU Hong HE Zhao-xia |
| Affiliation: | WANG Zhen-guo,ZHU Hong,HE Zhao-xia.Department of Obstetrics and Gynecology,The 309th Hospital of PLA,Beijing,100091,China |
| Abstract: | Objective To evaluate whether P53 gene mutation was related with the pathogenesis of ovarian malignant epithelial tumors or not.Methods P53 gene mutation in exons 5-8 was detected by polymerase chain reaction product-single strand conformation polymorphism analysis (PCR-SSCP).Results The mutation in benign tumors: 3(10%) cases, but in malignant epithelial tumor:19(38%) cases(P<0 05).The statistics does not show significant in different histological grade(P>0 05).Conclusions P53 gene mutation in exons 5-8 was probably related with the pathogenesis of ovarian malignant epithelial tumors, but was not related with histological grade. |
| Keywords: | Malignant epithelial tumor Ovarian P53gene Point mutation |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ | |