| THE ALTERNATIVE PATHWAY OF HUMAN T CELL ACTIVATION BY MONOCLONAL ANTIBODIES(A COMPARATIVE STUDY BETWEEN NORMAL INDIVIDUALS AND CANCER PATIENTS) |
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| 作者姓名： | 陈毓仙 夏汉章 章小英 李艳芬 陈凤 石卫 许秉责 黄一蓉 张友会 |
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| 作者单位： | Cancer Institute，Chinese Academy of Medical Sciences，Beijing，Cancer Institute，Chinese Academy of Medical Sciences，Beijing，Cancer Institute，Chinese Academy of Medical Sciences，Beijing，Cancer Institute，Chinese Academy of Medical Sciences，Beijing，Cancer Institute，Chinese Academy of Medical Sciences，Beijing，Cancer Institute，Chinese Academy of Medical Sciences，Beijing，Cancer Institute，Chinese Academy of Medical Sciences，Beijing，Cancer Institute，Chinese Academy of Medical Sciences，Beijing，Cancer Institute，Chinese Academy of Medical Sciences，Beijing |
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| 摘 要： | This paper described T cell proliferative response by an alternative pathway in normal subjects and In patients with malignant diseases. Two McAbs, Anti-CCTl and Lo-CD2-act recognizing two distinct epitopes on E-receptor (CD2) were used to costimulate PBMC. Proliferative responsiveness was measured by 3H-thymidine incorporation. It was found that 82% of 72 nonnal subjects gave proliferative response whereas only 23% of the 93 patients did. The average cpm±SD in patients with bladder cancer (118±2314), kidney cancer (1619±2719) or lymphoma (2518±4057) was significantly lower than that in normal subjects (4935±2314), (P<0.001). These results indicate that T cell proliferation through the alternative pathway was significantly depressed in patients with cancer, and this can be used as a new parameter to monitor the immune status of cancer patients.
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