梅毒患者与HLA—DRB1等位基因相关性研究 |
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引用本文: | 蒋红伟,田洪青,李中伟,李娜,赵毅,刘殿昌,刘兵,初同胜,侯建玲,郑荣涛.梅毒患者与HLA—DRB1等位基因相关性研究[J].中国麻风杂志,2010(5):303-306. |
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作者姓名: | 蒋红伟 田洪青 李中伟 李娜 赵毅 刘殿昌 刘兵 初同胜 侯建玲 郑荣涛 |
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作者单位: | 山东省皮肤病性病防治研究所,济南250022 |
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摘 要: | 目的:检测山东汉族梅毒患者与HLA-DRB1等位基因的相关性。方法:应用聚合酶链反应一序列特异性引物技术(PCR—ssp)对196例山东汉族梅毒患者与500例山东汉族正常对照的HLA-DRB1等位基因表现频率进行检测。结果:患者组DRB1*14等位基因的出现频率高于对照组(P〈0.05);DRB1*16等位基因的出现频率与对照组无显著差异(P〉0.05)。结论:HLA—DRB1*14等位基因可能是梅毒的易感基因。
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关 键 词: | 梅毒 HLA等位基因 聚合酶链反应-序列特异性引物技术 |
Association between HLA- DRB1 alleles and syphilis patients |
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Institution: | Jiang Hongwei, Tian Hongqing, Li Zhongwei, et al. (Shandong Provincial Institute of Dermatology and Venerology, Jinan, 250022) |
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Abstract: | Objective: To associate the HLA - DRBI alleles with syphilis patients in Shandong Hart Nationality. Method: The allele frequency of HLA - DRB1 was detected in 196 syphilis patients and 500 healthy controls by polymerase chain reaction- sequence specific primers (PCR- SSP). Results: The allele frequency of HLA- DRB1 14 was higher in syphilis patients when compared with the healthy controls (P 〈 0.05). There was no significant difference in the frequency of HLA- DRB1 * 16 between the two groups ( P 〉 0.05). Conclusion: HLA- DRB1 14 may be a susceptible gene of syphilis. |
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Keywords: | syphilis HLA alleles PCR- SSP |
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