泻火滋阴法治疗青年原发性高血压临床研究

目的：从＂泻火滋阴＂法揭示青年原发性高血压的发病机制和证型研究,为中医药诊治青年原发性高血压提供理论依据。方法：将100例符合纳入标准的青年原发性高血压患者采用单盲法随机分为治疗组50例,对照组50例。治疗组用泻火滋阴中药汤剂治疗,对照组给予吲达帕胺2.5mg,1天1次口服,两组疗程均为4周。于治疗前后进行24h动态血压监测并计算其谷峰比值和平滑指数。结果：治疗组降压疗效显效率56%,总有效78%,对照组分别为48%和72%,两组治疗前后比较差异有非常显著意义（P〈0.01）;两组治疗前后临床症状总积分明显下降,与组内比较差异有非常显著性意义（P〈0.01）,治疗组与对照组比较,差异有显著意义（P〈0.05）。两组治疗前后总胆固醇、甘油三酯、低密度脂蛋白比较,治疗组治疗后总胆固醇、甘油三酯、低密度脂蛋白均明显降低,与治疗前比较,与对照组比较,差异均有显著性（P〈0.05）;对照组治疗后无下降,差异无显著性（P〉0.05）;治疗组和对照组之间降压谷峰比值即（T/P）收缩压、舒张压差异有显著性（P〈0.05）;治疗组和对照组之平滑指数收缩压、舒张压较,差异有显著性（P〈0.05）。结论：阴虚火旺证是青年原发性高血压的一个重要证型,＂泻火滋阴＂法是治疗阴虚火旺型青年原发性高血压的重要治法。

Clinical research on the therapy for Young-Aged essential Hypertensive patients with Chinese medicine of nourishing yin and purging fire

Objectives： To study possible nosogenesis and pattern of syndrome of Young-Aged essential Hypertension,and provide the theoretical evidence for therapeutic effect of Chinese Medicine on Young-Aged essential Hypertension.Methods： Based on the enrolled criteria,one-hundred Young-Aged essential Hypertenial patients were randomly divided into the treatment group and the control group,each group was 50 patients.The treatment group was continuously given nourishing yin and purging fire decoction,and.the control group were continuously given 2.5mg indapamide once a day for 4 weeks.24h ambulatory blood pressure monitoring before and after therapy were measured,and the trough/peak（T/P ratio） and the smoothness index were calculated.Results： The marked effective rate of depressurization in Treatment groups was 56%,the total effective rate is 78%,and the control group was separately 48% and 72%;Pre-post therapic contrast of the marked and the total effective rate between two group was significant difference（P 0.01）.Ttotal score of clinical symptom in Pre-post contrast between the two group were all decreased,and all had statistical significance in inner group（P 0.01）.The total score of clinical symptom between the treatment group and the control group had significant difference（P 0.05）.Serum Cholesterol（TC）、Triglyceride（TG）、Low Density Lipoprotein（LDL） in Pre-post therapeutic contrast of the treatment group were all decreased.Compared with the control group,Serum TC、TG、LDL after the therapy in the treatment group were significant differences（P 0.05）.But Serum TC、TG、LDL in Pre-post therapeutic contrast of the control group has no difference.（P0.05）.The difference of T/P ratio of systolic blood pressure（SBP） and diastolic blood pressure（DBP） between the two groups were significant（P 0.05）;The difference of the smoothness index of SBP and DBP between the two grouop were significant（P 0.05）.Conclusion： Syndrome of hyperactivity of fire due to deficiency of YIN is important syndrome and nourishing yin,and purging fire is significant treatment method on Young-Aged Hypertensive patients of syndrome of hyperactivity of fire due to deficiency of YIN.