冠心平对垂体后叶素致心肌缺血的实验研究

目的：观察冠心平对大鼠实验性急性心肌缺血的保护作用。方法：采用大鼠尾静脉注射垂体后叶素（Pit）诱发急性心肌缺血模型,观察各组注射Pit后5min内心电图ST段、心率以及6h后血清乳酸脱氢酶（LDH）、超氧化物歧化酶（SOD）的变化,心肌病理损伤程度的影响。结果：冠心平对Pit所致急性缺血性心电图ST段和心率的变化都有明显改善作用,能显著降低L D H的含量,增加血清SOD的活性（P〈0.05,P〈0.01）,心肌病理损伤程度明显减轻。结论：冠心平对Pit致大鼠急性心肌缺血具有明显的保护作用。

An Experimental Study of GuanXinPing on Pituitrin-Induced Myocardial Ischemia

Objective：To study the protection effect of GuanXinPing on pituitary induced acute myocardium ischemia.Methods：Pituitrin（Pit） was given to form model of acute myocardium ischemia.The changes of ECG（ST-segment）,heart rate after injection Pit via caudal vein in 5 minutes later and contents of LDH/SOD in serum was observed after 6 hours later.And to observe the experimental animal cardiac pathological damage extent.Results：GuanXinPing group can significantly improved the height of ST-segment and heart rate.The SOD activity was significantly enhanced and LDH contents was significantly reduced（P〈0.05,P〈0.01）.Cardiac pathological damage is reduced significantly.Conclusion：GuanXinPing have the functions of anti-acute myocardium ischemia.