红芪多糖对2型糖尿病胰岛素抵抗大鼠胰岛素敏感性影响的研究

目的：探讨红芪多糖在2型糖尿病胰岛素抵抗中的防治效果及作用机制。方法：取50只wistar大鼠,随机选取10只作为空白对照,其余40只一次性注射链脲佐菌素（STZ）30mg/kg,并饲以高脂高糖饲料6周制作2型糖尿病胰岛素抵抗模型。6周后选取空腹血糖≥11.1mmol/L的大鼠随机分为模型组、红芪多糖组、二甲双胍组。各组分别灌服生理盐水、红芪多糖、二甲双胍1月。1月后取血清测空腹胰岛素、空腹血糖、总胆固醇（TC）、甘油三酯（TG）、高密度脂蛋白（HDL-C）的含量,并计算胰岛素敏感指数（ISI）。结果：与模型组相比,红芪多糖能显著降低2型糖尿病胰岛素抵抗大鼠空腹血糖（P〈0.05）。红芪多糖能调节2型糖尿病胰岛素抵抗大鼠的血脂紊乱,降低血清总胆固醇（P〈0.05）和甘油三酯（P〈0.05）,提高了高密度脂蛋白的含量（P〈0.05）,提高了胰岛素的敏感指数。结论：红芪多糖对2型糖尿病胰岛素抵抗大鼠有降低血糖、调节血脂紊乱的作用,并改善了胰岛素敏感指数,从而对2型糖尿病胰岛素抵抗具有一定的防治作用。

The Effects of Radixhedysari Polysaccharide on Insulin Sensitivity in T2DM Rats with Insulin Resistance

Objective： To investigate the effects of Radixhedysari polysaccharide（RP） on insulin sensitivity in T2DM rats with insulin resistance and the primary pharmacological mechanism.Methods： Ten rats were selected randomly as free group from fifty rats accord to sex and weight,others which make the model for type 2 diabetic insulin resistance（T2D-IR） rats were performed through intraperitonea injection of lower dosage of streptozocin（STZ） 30mg/kg and high caloric diet（abounded with sugar fat）six weeks.Then the rats whose free blood glucose（FBG） equals or surpasses 11.1mmol/L were selected and divided into model group,RP group,Metformin（MT）group randomly accord to sex and weight.After respectly giving fresh water,RP,MT for 30 days,the effects of RP on blood and/or serum contents of glucose、lipids、insulin and insulin sensitive index（ISI） were observed in the model rats.Results：RP insignificantly fasting free blood glucose（FBG）;decreased markedly the levels of total cholesterols（TC） and triglyceride（TG）,and increase the content of high-density lipoprotein cholesterol（HDL-C）;and reduced the concentration of insulin in hyperinsulinemia,and potentiated ISI in T2D-IR.Conclusion：Effects in the experiment with type 2 diabetic-resistant rats,RP can reduce level of blood glucose,regulate components and content of blood lipids,and improve insulin sensitity.