甲氨喋呤单用与甲氨喋呤联合米非司酮治疗异位妊娠临床效果分析

目的对甲氨喋呤（MTX）单枪肌肉注射与米非司酮配伍MTX保守治疗非破裂性异位妊娠的临床效果进行比较，探讨保守治疗异位妊娠的最佳治疗方案。方法对我院收治的符合异位妊娠保守治疗条件的40例患者随机分成两组，甲组20例，将MTX50mg单枪肌肉注射7天后，对未转阴者再追加给药一次；乙组20例，采用MTX联合米非司酮连续6日用药保守治疗，观察两组的临床治疗效果。结果疗程结束后复查尿HCG转阴率，甲组75％，乙组90％。复查B超：甲组除5例手术外，5例治疗后包块消失，10例略有缩小，乙组除2例手术外，8例治疗后包块消失，10例包块略有缩小。症状缓解情况：甲组症状消失时间5-11天，乙组症状消失时间5—9天。结论米非司酮配伍甲氨喋呤保守治疗非破裂性异位妊娠的效果好，值得临床推广应用。

Curative Effect Analysis of the Treatments with Methotrexate and with Methotrexate plus Mifepristone for Ectopic Pregnancy

Objective To compare the curative effect of the expectant treatment with intramuscular injection of methotrexate and that plus mifepristone for non-disruptive ectopic pregnancy.Methods 40 cases with ectopic pregnancy were randomly divided into 2 groups: Group A(n=20) and Group B(n=20);Intramuscular injection of methotrexate(50mg/once) was given to patients in Group A for 7 days,and one more injection was given to those whose HCG kept positive;For patients in Group B,besides the injection of methotrexate,mifepristone was given for 6 days.The effects in both groups were observed.Results After treatment,negative urine HCG was found in 75% patients in Group A 90% in Group B;the ultrasound recheck showed that the mass disappeared in 5 cases in Group A and in 8 cases in Group B,the mass contracted in 10 cases in Group A an 10 cases in Group B;the time for symptom relief was 5 to 11 days in Group A and 5 to 9 days in Group B.5 cases in Group A and 2 cases in Group B received operation.Conclusions The expectant treatment with intramuscular injection of methotrexate plus mifepristone for non disruptive ecotopic pregnancy is of good effect.