Single photon emission computed tomography (SPECT) with 99mTc-HMPAO (hexamethyl propylenamino oxime) in chronic paroxysmal hemicrania-a case report |
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Authors: | Hans-Peter Schlake,Ingolf Gerhard Bö ttger,Karl-Heinz Grotemeyer,Ingo Wilhelm Husstedt,Otmar Schober |
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Affiliation: | Department of Neurology, University of Münster, Federal Republic of Germany. |
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Abstract: | The case of a 69-year-old woman with chronic paroxysmal hemicrania (CPH) is presented in whom cerebral perfusion was investigated using the flow tracer 99mTc-hexamethyl propylenamino oxime (HMPAO) and single photon emission tomography (SPECT). There was a bilateral hypoperfusion in the fronto-parietal region between attacks--without medication as well as under effective treatment with verapamil. During an attack, however, SPECT investigation showed a normal cerebral perfusion. Further investigation is required to find out whether these SPECT findings are due to primary alterations of brain perfusion in CPH or are only of epiphenomenological nature. The observed effectiveness of verapamil in the prophylactic treatment of CPH should be verified in a greater number of patients. |
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Keywords: | Cerebral perfusion chronic paroxysmal hemicrania hexamethyl propylenamino oxime SPECT technetium-99m verapamil |
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