血管内皮生长因子表达与肺癌预后的相关性研究

目的　研究血管内皮生长因子（ 以下简称 Ｖ Ｅ Ｇ Ｆ） 表达与肺癌的预后相关性。方法　应用 Ｓ Ｐ 免疫组化方法研究 Ｖ Ｅ Ｇ Ｆ 在６０ 例肺癌患者组织中的表达。结果　 Ｖ Ｅ Ｇ Ｆ 阳性表达率为６０ ％ ， Ｖ Ｅ Ｇ Ｆ阳性表达主要出现在肺癌组织中癌细胞胞浆内， Ｖ Ｅ Ｇ Ｆ 表达与肺癌的淋巴结转移、复发有关：其中 Ｎ１ 、 Ｎ２（ ＋ ） 组 Ｖ Ｅ Ｇ Ｆ 阳性率分别为５３ ％ 、８０ ％ ，高于 Ｎ０ 组（２３ ％ ， Ｐ＜ ００１） ， Ｖ Ｅ Ｇ Ｆ 阳性表达率在肺癌复发组（８０ ％ ） 高于无复发组（５３ ％ ， Ｐ＜ ００５） ；３ 、５ 年生存率 Ｖ Ｅ Ｇ Ｆ（ ＋ ） 与 Ｖ Ｅ Ｇ Ｆ（ － ） 组分别为３１ ％ 、１１ ％ 和８８ ％ 、５０ ％ ；术后生存时间 Ｖ Ｅ Ｇ Ｆ 表达（ ＋ ） 组远低于 Ｖ Ｅ Ｇ Ｆ 表达（ － ） 组（ 分别为３１ ±７ 月，６４ ±７月， Ｐ＜ ００５） 。结论　 Ｖ Ｅ Ｇ Ｆ是促进肺癌组织血管生成的关键因素，是预测肺癌患者预后的重要指标。

Correlation between the expression of vascular endothelial growth factor and prognosis of lung cancinoma

OBJECTIVE: To determine the association between the expression of vascular endothelial growth factor (VEGF) and prognosis of lung cancer. METHODS: Apply the SP immunohistochemistry stain method to investigate the expression of VEGF in 60 specimens of patients with lung cancer, who had undergone curative resection more than 36 months before. RESULTS: The VEGF stain positive rate is 60% in 60 cases of lung cancer specimens; The immunoreactivity of VEGF was almost exclusively restricted to the tumor cells, the positive expression of VEGF showed significantly higher in the patients with lymph node metastasis and/or relapse. The positive rates of VEGF were higher in N1, N2 groups (53%, 80%) than in No group (23%, P < 0.01), and in relapse group (80%) than in non-relapse group (53%, P < 0.05). Postoperative survival time was shorter in VEGF(+) group (31 +/- 7 months) than in VEGF(-) group (64 +/- 7 months, P < 0.05). The 3, 5 year survival rates showed significant difference between VEGF(+) (31%, 11%) and VEGF(-) (88%, 50%) groups. CONCLUSIONS: The results suggest VEGF is a reliable prognostic parameter and antiangiogenesis therapy will be a useful strategy in treatment of the human lung cancer.