血管内皮生长因子和碱性成纤维细胞生长因子在甲状腺癌中的表达及临床意义

目的　探讨血管内皮生长因子 (VEGF)、碱性成纤维细胞生长因子 (bFGF)在甲状腺癌中的表达及临床意义。方法　用免疫组织化学SP法检测 90例甲状腺乳头状癌、14例甲状腺未分化癌和 10例正常甲状腺组织中VEGF、bFGF的表达情况 ,并分析其与相关临床病理因素的关系。结果在甲状腺癌组织中VEGF、bFGF表达阳性率分别为 6 3 5 %和 5 9 6 % ,均显著高于正常甲状腺组织( χ2 =12 5 81,P <0 0 1)、( χ2 =12 5 81,P <0 0 1) ;未分化癌组织中VEGF、bFGF的表达阳性率分别为 92 9%和 85 7% ,均显著高于乳头状癌 ( χ2 =6 0 2 9,P <0 0 5 )、( χ2 =4 5 77,P <0 0 5 ) ;VEGF和bFGF表达阳性率均与甲状腺癌淋巴结转移有关 ( χ2 =4 0 2 5 ,P <0 0 5 )、( χ2 =4 712 ,P <0 0 5 ) ;两者在甲状腺癌中的表达阳性率呈明显正相关性 (γ =0 5 96 ,P <0 0 5 )。结论　VEGF、bFGF是评价甲状腺癌生物学行为及预后的两个重要指标

Clinical significance of expression of VEGF and bFGF in thyroid carcinoma

OBJECTIVE: To study the clinical significance of expression of VEGF and bFGF in thyroid carcinoma. METHODS: Immunohistochemical SP technic was used to investigate the expression of VEGF and bFGF in 90 cases of papillary carcinoma, 14 cases of undifferentiated carcinoma, 10 cases of normal thyroid tissue. RESULTS: The positive rate of VEGF and bFGF in thyroid carcinoma was 63.5% and 59.6% respectively, Which was significantly higher than that in normal thyroid tissue (P < 0.01); The positive rate of VEGF and bFGF in undifferentiated carcinoma was 92.9% and 85.7% respectively, which was significantly higher than that in papillary carcinoma (P < 0.05); The positive rate of expression of VEGF and bFGF was correlated with lymph gland metastasis (P < 0.05); A positive correlation between these two expresses existed in thyroid carcinoma (gamma = 0.596, P < 0.05). CONCLUSION: VEGF and bFGF can be regarded as a parameter to evaluate the biological behavior and prognosis of thyroid carcinoma.