硫酰氟熏蒸除鼠的投药剂量与作用时间的响应面模型研究

目的：广谱熏蒸剂-硫酰氟熏蒸除鼠的投药剂量与作用时间的关系研究；方法：采用静式呼吸道吸人染毒法对各组大鼠进行熏蒸处理，观察中毒症状与死亡情况，运用二次响应面回归模型对实验数据进行拟合及预测，并经过现场模拟验证；结果：响应面模型有高度的显著性(P＜0．0001)，总决定系数R^2＝0．884，模型的一次项、二次项与交叉项均有统计学上的显著性意义，其决定系数分别为0．509，0．350，0．026，以该模型预测所得的硫酰氟除鼠剂量与作用时间值为依据进行现场模拟试验，除鼠率均达到100％；结论：根据本次研究基本确定了硫酰氟熏蒸除鼠的投药剂量与作用时间的关系，为今后熏蒸工作中没定正确的投药量与时间提供了科学的依据。

Response Surface Model of Proper Dosage and Exposure Time of a Broad Spectrum Fumigant, Sulfuryl Fluoride

Objective:To study the relationship between dosage and exposure time of a broad-spectrum fumigant sulfuryl fluoride in deratting. Methods:All groups of rats were fumigated using the method of static respiratory-tract inhalation. Symptoms of intoxication and death were recorded. The experimental data were simulated and predicted using response-surface model and also verified by field studies. Results:The response-surface model was highly significant in statistics(P< 0.000 1), total R 2 is 0.884. The linear, quadratic and crossproduct regression items were also significant, with the determining coefficients 0.509,0.350,0.026 respectively. All of the deratting rates attained 100% in field model mentioned above. Conclusion:The relationship between dosage and exposure time of sulfuryl fluoride in deratting is founded, which offers a scientific proof for the fumigation later.