An increase of abdominal pressure increases pulmonary edema in oleic acid-induced lung injury |
| |
Authors: | Quintel Michael Pelosi Paolo Caironi Pietro Meinhardt Jurgen Peter Luecke Thomas Herrmann Peter Taccone Paolo Rylander Christian Valenza Franco Carlesso Eleonora Gattinoni Luciano |
| |
Institution: | Institut für An?sthesiologie und Operative Intensivmedizin, Universit?tsklinikum, Mannheim, Mannheim, Germany. |
| |
Abstract: | Increased abdominal pressure is common in intensive care unit patients. To investigate its impact on respiration and hemodynamics we applied intraabdominal pressure (aIAP) of 0 and 20 cm H(2)O (pneumoperitoneum) in seven pigs. The whole-lung computed tomography scan and a complete set of respiratory and hemodynamics variables were recorded both in healthy lung and after oleic acid (OA) injury. In healthy lung, aIAP 20 cm H(2)O significantly lowered the gas content, leaving the tissue content unchanged. In OA-injured lung at aIAP 0 cm H(2)O, the gas content significantly decreased compared with healthy lung. The excess tissue mass (edema) amounted to 30 +/- 24% of the original tissue weight (455 +/- 80 g). The edema was primarily distributed in the base regions and was not gravity dependent. Heart volume, central venous, pulmonary artery, wedge, and systemic arterial pressures significantly increased. At aIAP 20 cm H(2)O in OA-injured lung, the central venous and pulmonary artery pressures further increased. The gas content further decreased, and the excess tissue mass rose up to 103 +/- 37% (tissue weight 905 +/- 134 g), with homogeneous distribution along the cephalocaudal and sternovertebral axis. We conclude that in OA-injured lung, the increase of IAP increases the amount of edema. |
| |
Keywords: | |
本文献已被 PubMed 等数据库收录! |
|