| 苯佐卡因凝胶剂药效学实验研究 |
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| 引用本文： | 周卫,吴晓兰.苯佐卡因凝胶剂药效学实验研究[J].药学与临床研究,2000,8(4):7-9. |
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| 作者姓名： | 周卫 吴晓兰 |
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| 作者单位： | 江苏省药物研究所南京210009 |
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| 摘 要： | 将苯佐卡因制成以卡波姆为基质的外用凝胶剂，进行了药效学实验、口腔粘膜刺激性实验和急性毒性实验。结果表明苯佐卡因凝胶药效明显，与对照组有显差异；使用后口腔粘膜未见刺激性；口服及腹腔注射LD50分别为1327．9mg／kg及1222．6mg／kg。
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| 关 键 词： | 苯佐卡因 凝胶剂 制备工艺 药效学试验 急性毒性试验 卡波姆 局部麻醉药 |
| 收稿时间： | 2000/3/3 0:00:00 |
Study on Preparation of Benzocain Gel and Its Pharmacodynamics |
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| Zhou Wei and Wu Xiaolan.Study on Preparation of Benzocain Gel and Its Pharmacodynamics[J].Pharmacertical and Clinical Research,2000,8(4):7-9. |
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| Authors: | Zhou Wei and Wu Xiaolan |
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| Abstract: | This paper introduces the preparation of a topic gel- Benzocain gel made using carbomer 934P. The results of pharmacodynamics show that its effects are obvious and the LD50 are 1327.9 mg/kg(po) and 1222. 6 mg/kg(ip). |
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| Keywords: | Benzocain Gel Preparation Pharmacodynamics LD50 |
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