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| 高压氧对脑缺血大鼠脑组织内皮素及降钙素基因相关肽含量的影响 | |
| 引用本文： | 王伯平,孙乐天,贾钢锐.高压氧对脑缺血大鼠脑组织内皮素及降钙素基因相关肽含量的影响[J].中华航海医学与高气压医学杂志,2003,10(4):230-231. |
| 作者姓名： | 王伯平 孙乐天 贾钢锐 |
| 作者单位： | 1. 266071,青岛,解放军第四○一医院神经内科 2. 266071,青岛,解放军第四○一医院手外科 3. 266071,青岛,解放军第四○一医院放射中心 |
| 摘 要： | 目的 探讨高压氧(HBO)对大鼠脑缺血后脑组织内皮素(ET-1)及降钙素基因相关肽(CGRP)含量的影响。方法 采用双侧颈总动脉结扎法制作脑缺血动物模型．经HBO暴露后．用放射免疫法测定大鼠脑组织ET—1及CGRP的含量。结果 脑缺血组大鼠脑组织ET-1的含量升高，而CGRP的含量降低；经HBO暴露后，抑制了缺血大鼠脑组织ET—1含量的升高及CGRP含量的降低。结论 HBO对脑缺血大鼠脑组织ET1及CGRP的含量有影响。 |
| 关 键 词： | 高压氧 脑缺血 大鼠 脑组织 内皮素 降钙素基因相关肽 放射免疫法 |
| 修稿时间： | 2002年12月31 |
Effects of hyperbaric oxygenation on the content of endothelin and calcitonin gene-related peptide in the brain tissue of ischemic rats |
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| WANG Bo-ping,SUN Le-tian,JIA Gang-rui.No. Hospital QingDao ,China.Effects of hyperbaric oxygenation on the content of endothelin and calcitonin gene-related peptide in the brain tissue of ischemic rats[J].Chinese Journal of Nautical Medicine and Hyperbaric Medicine,2003,10(4):230-231. | |
| Authors: | WANG Bo-ping SUN Le-tian JIA Gang-ruiNo Hospital QingDao China |
| Institution: | WANG Bo-ping,SUN Le-tian,JIA Gang-rui.No.401 Hospital QingDao 266071,China |
| Abstract: | Objective To study changes of endothelin and calcitonin gene-related peptide content in the brain tissue of ischemic rats after cerebral ischemia and hyperbaric oxygenation.Methods Cerebral ischemia model is made by ligating bilateral common carotid arteries of the rat. Changes of endothelin and calcitonin gene-related peptide content in the brain tissue were determined by radioimmunoassay.Results After ischemia,the endothelin content of the ischemia group was distinctively increased,compared with the control group;the calcitonin gene-related peptide content of the ischemia group was distinctively reduced,compared with the control group.After hyperbaric oxygenation therapy,these changes of endothelin and calcitonin gene-related peptide content were suppressed.Conclusions Hyperbaric oxygenation therapy has distinctive inflenuce on levels of endothelin and calcitonin gene-related peptide in the brain tissue of ischemic rats. |
| Keywords: | Hyperbaric oxygen Cerebral ischemia Rat Brain tissue Endothelin Calcitonin gene-related peptide |
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