| 虫草多糖对8-MOP／UVA诱导光老化皮肤成纤维细胞胶原的影响 |
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| 引用本文： | 李华,叶杰,李伯勤,应馨萍.虫草多糖对8-MOP／UVA诱导光老化皮肤成纤维细胞胶原的影响[J].上海中医药大学学报,2009(4):75-78. |
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| 作者姓名： | 李华 叶杰 李伯勤 应馨萍 |
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| 作者单位： | 上海中医药大学基础医学院;上海中医药大学教学实验中心; |
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| 基金项目： | 上海市教委青年基金资助项目(05cz02);;上海市教委重点学科建设项目(J50301) |
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| 摘 要： | 目的：探讨虫草多糖（CP）对皮肤成纤维细胞光老化保护作用中对胶原的影响。方法：用8-甲氧补骨脂素联合UVA（8-MOP／UVA）诱导皮肤成纤维细胞光老化，用电镜观察、羟脯氨酸含量、丙二醛含量测定及免疫细胞化学等方法观察虫草多糖对成纤维细胞光老化过程中胶原的影响。结果：光老化组细胞较对照组蛋白合成功能不活跃，羟脯氨酸含量下降，丙二醛含量升高，Ⅰ型胶原表达降低，Ⅲ型胶原表达增高，虫草保护组细胞有所改善。结论：虫草多糖对8-MOP／UVA诱导光老化的皮肤成纤维细胞胶原变化具有逆转作用。
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| 关 键 词： | 虫草多糖 成纤维细胞 光老化 Ⅰ型胶原 Ⅲ型胶原 |
Effects of Cordyceps Polysaccharides on Fibroblasts Collagens in Photoaging Skin Induced by 8-MOP/UVA |
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| LI Hua YE Ting-jie LI Bo-qing YING Xin-ping.Basic Medicine School,Shanghai University of Traditional Chinese Medicine.Teaching Experiment Center,Shanghai University of Traditional Chinese Medicine.Effects of Cordyceps Polysaccharides on Fibroblasts Collagens in Photoaging Skin Induced by 8-MOP/UVA[J].Acta Universitatis Traditionis Medicalis Sinensis Pharmacologiaeque Shanghai,2009(4):75-78. |
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| Authors: | LI Hua YE Ting-jie LI Bo-qing YING Xin-pingBasic Medicine School Shanghai University of Traditional Chinese MedicineTeaching Experiment Center Shanghai University of Traditional Chinese Medicine |
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| Institution: | LI Hua1 YE Ting-jie1 LI Bo-qing2 YING Xin-ping21.Basic Medicine School,Shanghai University of Traditional Chinese Medicine2.Teaching Experiment Center,Shanghai University of Traditional Chinese Medicine |
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| Abstract: | Objective： To study the effects of cordyceps polysaccharides （CP） on fibroblasts collagens in photoaging skin. Methods： The Photoaging skin fibroblast modds were induced by 8-MOP/UVA. TEM, hydroxyprohne（HYP） ,MDA quantity and immunocytochemistry were used to test the effects of cordyceps polysaccharides on collagens. Results： Compared with the control group, it was noted that the protein synthesis was not active, the content of HYP was decreased and the content of MDA was increased, the expression of Collagen Ⅰ was decresed, and that of Collagen Ⅲ was increased in the model group. While, these abnormal changes were alleviated in the CP group. Conclusion： Cordyceps polysaccharides can reverse the abnormal changes of fibroblasts collegens in photoaging skin. |
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| Keywords: | Cordyceps polysaccharides（CP） fibroblast photoaging collagen Ⅰ collagen Ⅲ |
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