慢性乙型肝炎血清可溶性L-选择素及细胞间粘附分子-1与肝功能损害的相关性研究

目的：探讨乙型肝炎患者血清可溶性L-选择素(L-Selectin)、可溶性细胞间粘附分子-1(ICAM-1)水平与肝功能损害的相关性。方法：应用ELISA法检测50例慢性乙型肝炎和10例正常人血清可溶性L-Selectin、ICAM-1的水平，同时检测肝功相关生化指标。结果：慢性乙型肝炎患者血清L-选择素和细胞间粘附分子-1水平均明显高于正常人，均与肝功能损害呈不同程度的正相关。结论：L-选择素和细胞间粘附分子-1均参与乙肝病毒感染后的肝功能损害过程，血清L-选择素和细胞间粘附分子-1特别是后者的水平可作为反映慢性乙肝患者肝功能损害程度的指标之一。

The Study of the Relationship between the Soluble L-Selectin,the Soluble Intercellular Adhesion Molecule-1(ICAM-1)and Liver Function in the Serum of Patients with Chronic Hepatitis B

Objective:To study the relationship between the soluble L-Selectin,the soluble intercellular adhesion molecule-1(ICAM-1)and liver function in the serum of patients with chronic hepatitis B.Methods: To measure the serum L-Selectin level and ICAM-1 level in 50 patients with chronic hepatitis B,10 healthy controls using an enzyme-linked immunosorbent assay (ELISA).Meanwhile,measuring the liver function.Results:Both the serum L-Selectin and the serum ICAM-1 levels were significantly higher than those in controls, and having the positive relationship with the indexes of liver function injury respectively.Conclusions:Both L-Selectin and ICAM-1 play roles in the process of liver function injury in the chronic hepatitis B.Both the serum levels of them,especially the ICAM-1,in chronic hepatitis B could be deemed as the indexes reflecting the severity of liver function injury.