| 血栓相关分子标志物在糖尿病血瘀证中的临床意义 |
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| 引用本文： | 石志芸,施赛珠.血栓相关分子标志物在糖尿病血瘀证中的临床意义[J].中医杂志,1999,40(9):554-555. |
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| 作者姓名： | 石志芸 施赛珠 |
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| 作者单位： | 上海医科大学附属华山医院，上海医科大学附属华山医院，上海医科大学附属华山医院，上海医科大学附属华山医院，上海医科大学附属华山医院 上海市乌鲁木齐路12号 200040，上海市乌鲁木齐路12号 200040，上海市乌鲁木齐路12号 200040，上海市乌鲁木齐路12号 200040，上海市乌鲁木齐路12号 200040 |
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| 摘 要： | 以血浆α－颗粒膜蛋白（ＧＭＰ－１４０）、组织型纤溶酶原激活剂（ｔＰＡ）、纤维酶原激活物抑制剂（ＰＡＩ－Ｉ）、凝血酶－抗凝血酶Ⅲ复合物（ＴＡＴ）和血浆纤溶酶－α２抗纤溶酶抑制物（ＰＡＰ）、内皮素（ＥＴ）等血栓前状态分子标志物，探讨与糖尿病血瘀证的相关性。结果显示，糖尿病血瘀证患者存在着血小板活化、内皮细胞受损、纤溶酶的改变，其血浆ＧＭＰ－１４０、ＴＡＴ、ＰＡＰ、ＥＴ均高于非血瘀证和正常对照组。提示血
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| 关 键 词： | 糖尿病 血瘀 诊断 GMP－140 tPA |
Clinical Significance of Thrombo Molecular Markers in Blood-stasis Syndrome in Diabetes Mellitus |
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| Shi Zhiyun,Shi Saizhu,Chen Jianqiu,et al..Clinical Significance of Thrombo Molecular Markers in Blood-stasis Syndrome in Diabetes Mellitus[J].Journal of Traditional Chinese Medicine,1999,40(9):554-555. |
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| Authors: | Shi Zhiyun Shi Saizhu Chen Jianqiu |
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| Institution: | Shi Zhiyun,Shi Saizhu,Chen Jianqiu,et al.
Authors' address: Huashan Hospital Affiliated to Shanghai Medical University,Shanghai 200040 |
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| Abstract: | By applying the thrombo pre molecular markers, including plasmal GMP - 140, tPA, PAI - I TAT, PAP, ET, their correlation with blood stasis type diabetes were explored. Results showed that, the diabetic with blood -stasis type revealed the activation of platelets, injury of endothelial cells, changes of fibrinolysin. Their plasmal GMP-140, TAT, PAP, ET were all higher than that of the control group, indicating that the activation of platelets, injury of endothelial cells, and changes in the balance of blood coagulation/fibrinolysis are likely to benefit the incidence of blood stasis. The pathophysiological mechanism in blood stasis type diabetes is related to the changes in platelet, endothelial cells, blood coagulation and fibrinolysis. |
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| Keywords: | Diabetes mellitus/diagnosis blood stasis/ diagnosis@thrombo molecular markers |
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