| 高效液相色谱法测定降脂益肝胶囊中丹参酮Ⅱ_A的含量 |
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| 引用本文： | 滕桂珍,仲崇林,杨美林,刘诗月.高效液相色谱法测定降脂益肝胶囊中丹参酮Ⅱ_A的含量[J].中国药房,2003(9). |
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| 作者姓名： | 滕桂珍 仲崇林 杨美林 刘诗月 |
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| 作者单位： | 长春市传染病医院，吉林省中医中药研究院，吉林省中医中药研究院，吉林省中医中药研究院 长春市 130062，长春市 130021，长春市 130021，长春市 130021 |
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| 摘 要： | 目的:建立测定降脂益肝胶囊中丹参酮Ⅱ_A含量的高效液相色谱方法。方法:色谱柱为Hypersil ODS(4.6mm×250mm,5μm),流动相为甲醇-水(73:27),检测波长为270nm,流速为1ml/min。结果:丹参酮Ⅱ_A的线性范围为0.0 816～0.4 080μg/ml,r=0.9 999;加样平均回收率为99.12％(RSD=140);日内精密度为1.32％。结论:本方法具有简便、准确、灵敏且重现性好的特点,可用于该制剂的质量控制。
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| 关 键 词： | 降脂益肝胶囊 丹参酮Ⅱ_A 高效液相色谱法 含量测定 |
Determination of Tanshinone Ⅱ_A in Jiangzhiyigan Capsule by HPLC |
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| TENG Guizhen,ZHONG Chonglin,YANG Meilin,LIU Shiyue Changchun Hospital of Infectious Diseases,Changchun Jilin Academy of Chinese Traditional Medicine,Chang.Determination of Tanshinone Ⅱ_A in Jiangzhiyigan Capsule by HPLC[J].China Pharmacy,2003(9). |
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| Authors: | TENG Guizhen ZHONG Chonglin YANG Meilin LIU Shiyue Changchun Hospital of Infectious Diseases Changchun Jilin Academy of Chinese Traditional Medicine Chang |
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| Institution: | TENG Guizhen,ZHONG Chonglin,YANG Meilin,LIU Shiyue Changchun Hospital of Infectious Diseases,Changchun 130062 Jilin Academy of Chinese Traditional Medicine,Chang 130021 |
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| Abstract: | To establish a method for the determination of tanshinone Ⅱ A in Jiangzhiyigan capsules by
HPLC. METHODS: Hypersil C_(18)(4.6mm×250mm, 5μm) was used as analysis column. The mobile phase was methanol -- water
(73:27) .Detection wavelength was 270nm .The flow rate was 1ml/min .RESULTS: The calibration curves was linear in the
concentration range of 0.0 816～0.4 080μg/ml, r=0.9 999 .The average recovery was 99.12% (RSD=1.40), within -- day
RSD was 1.32% .CONCLUSION: This method is simple, accurate, sensitive and repeatable and it is suitable for the quality
control of the Jiangzhiyigan capsules. |
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| Keywords: | Jiangzhiyigan capsule tanshinone Ⅱ_A HPLC content determination |
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