马来酸曲美布汀与埃索美拉唑联合治疗胃食管反流病的临床疗效及安全性分析

目的探讨马来酸曲美布汀与埃索美拉唑联合治疗胃食管反流病的临床疗效及安全性。方法68例胃食管反流病患者,通过抽签的方式分为对照组和实验组,每组34例。对照组实施埃索美拉唑治疗,实验组实施马来酸曲美布汀与埃索美拉唑联合治疗。比较两组治疗效果、不良反应发生率。结果实验组治疗总有效率为97.06%,高于对照组的82.35%,差异有统计学意义(P<0.05)。对照组不良反应发生率为8.82%,与实验组的11.76%比较,差异无统计学意义(χ^2=0.159,P=0.690>0.05)。结论在胃食管反流病患者的用药治疗中,马来酸曲美布汀与埃索美拉唑联合治疗具有良好的治疗效果以及用药安全性,值得推广。

Clinical efficacy and safety of trimebutine maleate combined with esomeprazole in the treatment of gastroesophageal reflux disease

Objective To discuss the clinical efficacy and safety of trimebutine maleate combined with esomeprazole in the treatment of gastroesophageal reflux disease.Methods A total of 68 patients with gastroesophageal reflux disease were divided into control group and experimental group according to lottery method,with 34 cases in each group.The control group was treated with esomeprazole,and the experimental group was treated with trimebutine maleate combined with esomeprazole.The therapeutic effect and incidence of adverse reactions were compared between the two groups.Results The total effective rate of treatment of the experimental group was 97.06%,which was higher than 82.35%of the control group,and the difference was statistically significant(P<0.05).The incidence of adverse reactions of the control group was 8.82%,which had no statistically significant difference compared with 11.76%of the experimental group(χ^2=0.159,P=0.690>0.05).Conclusion Trimebutine maleate combined with esomeprazole has good therapeutic effect and high medication safety in the treatment of gastroesophageal reflux disease,which is worthy of promotion.