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Age-dependent copy number variations of TP53 tumour suppressor gene associated with altered phosphorylation status of p53 protein in sporadic schwannomas |
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| Authors: | Chen Hongsai Huang He Zhao Jingjing Wang Zhigang Chang Mengling Xue Lu Zhu Weidong Chai Yongchuan Li Gen Wang Zhaoyan Wu Hao |
| Affiliation: | 1.Department of Otolaryngology Head & Neck Surgery, The Ninth People’s Hospital, School of Medicine, Shanghai Jiao Tong University, No. 639, Zhi-Zao-Ju Road, Shanghai, 200011, China ;2.Ear Institute, School of Medicine, Shanghai Jiao Tong University, Shanghai, China ;3.Shanghai Key Laboratory of Translational Medicine On Ear and Nose Diseases, Shanghai, China ;4.Shanghai Institute of Precision Medicine, The Ninth People’s Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China ;5.Department of Burn and Plastic Surgery, Shanghai Jiao Tong University, School of Medicine, Rui Jin Hospital, Shanghai, China ; |
| Abstract: | Journal of Neuro-Oncology - Point mutations of TP53 tumour suppressor are very rare in schwannomas. We aim to characterize the frequency of exonic copy-number changes of the gene in the tumour and... |
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