自然病理实验揭示血管球体与井穴和宣穴高度相关

十二井穴与十宣穴虽然属于人体不同的经络和部位，但都有相同的清热、醒神等特殊作用，提示这些穴位可能有相似的解剖结构和针灸靶点。本研究首次采用了“针灸自然病理实验”（NPEA）的方法探索针灸原理，提出了“证实解剖结构与针灸靶点相关的标准”。通过分析人体手足常见的15种软组织肿瘤，发现血管球瘤（Glomus tumor）的分布与井宣穴相关性最高。对近10年中国知网中671例血管球瘤病报告分析表明，发生在手足的占比87%；在手足血管球瘤中，发生在甲下及甲旁肿瘤占比85%，与井宣穴的分布高度一致。结果提示产生血管球瘤的正常解剖结构，血管球体（Glomus body）可能是针灸的靶点。支持这个假说的证据包括，血管球体的解剖分布、生理功能、病理变化及临床特征等均同井宣穴高度相关。目前有关人体血管球体的分子生物学原理所知甚少，深入研究不但会有益于解释体温和血液循环的周围调节机制，还可能发现针灸井穴和宣穴的特异靶点和机制，进而提高临床治疗的效果。

Natural pathological experiments reveal significant correlation of Jing and Xuan acupoints with glomus bodies

Although 12 Jing and 10 Xuan acupoints belong to different meridians and regions of the human body,these acupoints all share specific functions of clearing heat and activating the mind,suggesting that these acupoints may have similar anatomical structures and common acupuncture targets.This study is the first to use the method of Natural Pathological Experiment for Acupuncture (NPEA) to explore the principles of acupuncture.The essential criteria for confirming the correlation between anatomical structures and acupuncture targets are proposed.By analyzing 15 common soft tissue tumors of human hands and feet,it was found that the distribution of glomus tumor correlates most closely with Jing and Xuan acupoints.An analysis of 671 cases of glomus tumors reported in China in the past 10 years showed that 87% of glomus tumors occurred in the hands and feet,and among them,85% located in the subungual and paranail of the fingers and toes.This pattern is highly consistent with the distribution of Jing and Xuan acupoints.These results suggest that glomus body,the normal anatomical structure that glomus tumor originates from,may be the target of acupuncture.The evidence supporting this hypothesis includes the anatomical distribution,physiological functions,pathological changes,and clinical characteristics of the glomus body are all closely related to Jing and Xuan acupoints.Since very little is known about the molecular mechanism of glomus body at present time,further in-depth research will not only help to understand the peripheral regulations of body temperature and blood circulation,but also may discover the specific targets and mechanism of acupuncture and moxibustion at Jing and Xuan acupoints,thereby improving the precise effect of clinical treatment.